{"id":"hum0141","version":1,"url":"https://humandbs.dbcls.jp/research/hum0141/v1","datePublished":"2019-05-09","versions":[{"version":1,"datePublished":"2019-05-09"}],"title":{"ja":"制御性T細胞特異的エピゲノム誘導による免疫制御の研究","en":"Immune regulation by cotrolling regulatory T cell-specific epigenome"},"summary":{"aims":{"ja":"頭頸部がんにおける免疫制御の解明","en":"Analysis of immune regulation in head and neck cancer"},"methods":{"ja":"RNA-seq","en":"RNA-seq"},"targets":{"ja":"頭頸部がん","en":"Head and neck cancer"},"url":{"ja":[{"url":"http://www.med.nagoya-cu.ac.jp/immunol.dir/index.html","text":"http://www.med.nagoya-cu.ac.jp/immunol.dir/index.html"}],"en":[{"url":"http://www.med.nagoya-cu.ac.jp/immunol.dir/new1.html","text":"http://www.med.nagoya-cu.ac.jp/immunol.dir/new1.html"}]}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"頭頸部癌：4症例\n（日本人）","en":"Head and neck cancer: 4 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（RNA-seq）","en":"NGS\n(RNA-seq)"}},"releaseNote":{"ja":"頭頚部がん4症例の腫瘍組織から単離したTreg細胞や類縁細胞から抽出したRNA15検体を用いたRNA-Seq解析データをfastqファイルにて提供する。KAPA Library Preparation KitによるRNAライブラリ作製後、Thermo Fisher Scientific [Ion S5]にて平均長150 bpを読んだ（Single-end）。","en":"RNAs extracted from isolated cells using different markers from tumor tissues of head and neck cancers. Libraries for RNA-seq were prepared with KAPA Library Preparation Kit and RNA-seq was performed with Thermo Fisher Scientific [Ion S5] (150 bp on average, Single-end). RNA-seq data are provided as fastq."},"dataProviders":[{"name":{"ja":"坂口 志文","en":"Shimon Sakaguchi"},"organization":{"name":{"ja":"大阪大学免疫学フロンティア研究センター 実験免疫学","en":"Experimental Immunology, IFReC, Osaka University"}}}],"researchProjects":[{"name":{"ja":"名古屋市立大学大学院医学研究科免疫学教室","en":"Department of Immunology, Nagoya City University Graduate School of Medical Sciences"},"url":{"ja":[{"url":"http://www.med.nagoya-cu.ac.jp/immunol.dir/index.html","text":"http://www.med.nagoya-cu.ac.jp/immunol.dir/index.html"}],"en":[{"url":"http://www.med.nagoya-cu.ac.jp/immunol.dir/new1.html","text":"http://www.med.nagoya-cu.ac.jp/immunol.dir/new1.html"}]}}],"grants":[{"title":{"ja":"加齢で増加する制御性T細胞による免疫抑制機構の解明","en":"Investigating the mechanisms of regulatory T cell expansion by aging"},"agency":{"ja":"科学研究費助成事業 挑戦的萌芽研究","en":"KAKENHI Grant-in-Aid for challenging Exploratory Research"},"grantIds":["26670192"]},{"title":{"ja":"皮膚希少癌における制御性T細胞の解析と新規免疫療法の有効性の研究","en":"Investigating regulatory T cells in skin rare cancer to predict effectiveness of a new immunotherapy"},"agency":{"ja":"科学研究費助成事業 挑戦的萌芽研究","en":"KAKENHI Grant-in-Aid for challenging Exploratory Research"},"grantIds":["16K15259"]},{"title":{"ja":"日本発の安全で有効な免疫抑制法-発癌や重篤感染を誘因しない制御性T細胞療法の研究","en":"Research on regulatory T cell-therapy without inducing cancer and severe infections-the safe and effective immunosuppression from Japan"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["16H05177"]},{"title":{"ja":"口腔癌特異的C5a受容体阻害剤の開発と癌増殖メカニズムの解明（今井優樹）","en":"Developing C5a antagonists specific for oral cancer and investigating mechanisms of cancer proliferation (M.I.)"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["17K11679"]},{"title":{"ja":"制御性T細胞に着目した頭頸部癌における抗腫瘍免疫の解析と免疫治療への応用（的場拓磨）","en":"Investigating roles of regulatory T cells in inducing anti-tumur immunity and developing immunotherapy in head and neck cancer (T.M.)"},"agency":{"ja":"科学研究費助成事業 若手研究（B）","en":"KAKENHI Grant-in-Aid for Young Scientists (B)"},"grantIds":["17K16937"]},{"title":{"ja":"紫外線で誘導されるネオ・セルフと制御性T細胞による自己免疫治療法の開発","en":"Developing a new therapy for autoimmnue dieseases using regulatory T cell and neo-self induced by ultraviolet"},"agency":{"ja":"科学研究費助成事業 新学術領域研究（研究領域提案型）","en":"KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)"},"grantIds":["17H05798"]}],"relatedPublications":[{"title":"Regulatory T cells expressing abundant CTLA-4 on the cell surface with a proliferative gene profile are key features of human head and neck cancer.","doi":"https://doi.org/10.1002/ijc.32024","datasets":["JGAD000204"]}],"datasets":["JGAD000204"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000204"]}]}