{"id":"hum0136","version":3,"url":"https://humandbs.dbcls.jp/research/hum0136/v3","datePublished":"2021-10-01","versions":[{"version":1,"datePublished":"2018-05-22"},{"version":2,"datePublished":"2021-03-05"},{"version":3,"datePublished":"2021-10-01"}],"title":{"ja":"B型肝炎に関する統合的臨床ゲノムデータベースの構築を目指す研究","en":"Construction of integrated clinical genome database regarding hepatitis B related diseases"},"summary":{"aims":{"ja":"B型肝炎ワクチンの効果に関連する宿主遺伝因子の同定","en":"To identify host genetic factors associated with response to a HB vaccination"},"methods":{"ja":"ゲノムワイド関連解析","en":"Genome-wide association study"},"targets":{"ja":"日本人B型肝炎ワクチン（ビームゲン）接種者1,193例、日本人B型肝炎ワクチン（ヘプタバックス）接種者555例","en":"1,193 Japanese individuals vaccinated with a HB vaccine (Bimmugen) and 555 Japanese individuals vaccinated with a HB vaccine (Heptavax)"},"url":{"ja":[{"url":"https://kohnodai.jihs.go.jp/genome/genome_ds/index.html","text":"https://kohnodai.jihs.go.jp/genome/genome_ds/index.html"}],"en":null}},"listingSummary":{"methods":{"ja":"ゲノムワイド関連","en":"Genome-wide association study"},"targets":{"ja":"B型肝炎ワクチン接種者（ビームゲン）：1,193名\nB型肝炎ワクチン接種者（ヘプタバックス）：555名\n（日本人）","en":"1,193 individuals vaccinated with a HB vaccine (Bimmugen)\n555 individuals vaccinated with a HB vaccine (Heptavax)\n(Japanese)"},"typeOfData":{"ja":"SNP-chip","en":"SNP-chip"}},"releaseNote":{"ja":"日本人B型肝炎ワクチン（ビームゲン）接種者1,193名の末梢血から抽出したDNAを対象としたSNPアレイ（Affymetrix AXIOM genome-Wide ASI 1 array）によるGenotype決定の際の個人毎のSNPアレイデータをCELファイルにて提供する。","en":"Individual genotype data for 1,193 Japanese individuals vaccinated with a HB vaccine (Bimmugen) is provided (CEL files)."},"dataProviders":[{"name":{"ja":"溝上 雅史","en":"Masashi Mizokami"},"organization":{"name":{"ja":"国立国際医療研究センター","en":"Natinal Center for Global Health and Medicine"}}}],"researchProjects":[{"name":{"ja":"ゲノム医科学プロジェクト","en":"Genome Medical Science Project"},"url":{"ja":null,"en":[{"url":"https://kohnodai.jihs.go.jp/genome/english/index.html","text":"https://kohnodai.jihs.go.jp/genome/english/index.html"}]}}],"grants":[{"title":{"ja":"B型肝炎に関する統合的臨床ゲノムデータベースの構築を目指す研究","en":"Construction of integrated clinical genome database regarding hepatitis B related diseases"},"agency":{"ja":"日本医療研究開発機構（AMED）臨床ゲノム情報統合データベース整備事業","en":"Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science Program for an Integrated Database of Clinical and Genomic Information"},"grantIds":["JP16kk0205007"]},{"title":{"ja":"ゲノム網羅的解析によるB型肝炎ウイルス感染の病態関連遺伝子の同定と新規診断法の開発","en":"Identification of genes associated with hepatitis B virus-related diseases by genome-wide analyses"},"agency":{"ja":"日本医療研究開発機構（AMED）肝炎等克服緊急対策研究事業","en":"Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science Program for Basic and Clinical Research on Hepatitis"},"grantIds":["JP16fk021010"]},{"title":{"ja":"B型肝炎ウイルス排除、慢性化および肝発がんの機序解明を目指す研究","en":"Elucidation of the pathogenesis for HBV clearance, chronic hepatitis B infection, and hepatocellular carcinoma"},"agency":{"ja":"日本医療研究開発機構（AMED）B型肝炎創薬実用化等研究事業","en":"Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science Program on the Innovative Development and the Application of New Drugs for Hepatitis B"},"grantIds":["JP17fk0310115"]},{"title":{"ja":"B型慢性肝炎とHLA class II遺伝子との関連の包括的理解を目指す研究","en":"Comprehensive understanding for the relationship between HLA class II genes and chronic hepatitis B infection"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["16K09387"]},{"title":{"ja":"B型肝炎ウイルスおよびヒトゲノムの解析に基づくクリニカルシークエンスに向けた研究","en":"Study for clinical sequening based on genome analysis of host and viral factors"},"agency":{"ja":"日本医療研究開発機構（AMED）肝炎等克服緊急対策研究事業","en":"Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science Program for Basic and Clinical Research on Hepatitis"},"grantIds":["JP20fk0210056"]}],"relatedPublications":[{"title":"Key HLA-DRB1-DQB1 haplotypes and role of the BTNL2 gene for response to a hepatitis B vaccine","doi":"https://doi.org/10.1002/hep.29876","datasets":["NHA000071"]},{"title":"Importance of HBsAg recognition by HLA molecules as revealed by responsiveness to different hepatitis B vaccines","doi":"https://doi.org/10.1038/s41598-021-82986-8","datasets":["NHA000160"]}],"datasets":["JGAD000452","NHA000071","NHA000160"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"宮川 卓","en":"TAKU MIYAGAWA"},"affiliation":{"ja":"睡眠プロジェクト, 東京都医学総合研究所","en":"Sleep Disorders Project, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"過眠を呈する睡眠障害（各種過眠症・概日リズム睡眠障害・睡眠時無呼吸症候群・睡眠関連運動障害・睡眠時随伴症など）の病態に関与する遺伝子の探索とその機能及び末梢血リンパ球の自己抗原特異的増殖反応の研究","en":"Search for genes involved in the pathogenesis of sleep disorders presenting with hypersomnia (various hypersomnias, circadian rhythm sleep disorders, sleep apnea syndrome, sleep-related movement disorders, sleep paralysis, etc.) and study of their functions and autoantigen-specific responses of peripheral blood lymphocytes"},"periodStart":"2023-07-21","periodEnd":"2027-03-31","datasets":["JGAD000452"]}]}