{"id":"hum0134","version":1,"url":"https://humandbs.dbcls.jp/research/hum0134/v1","datePublished":"2018-04-06","versions":[{"version":1,"datePublished":"2018-04-06"}],"title":{"ja":"Bリンパ腫の転移/再発に特徴的な遺伝子変異の同定","en":"Identification of genetic mutations characteristic for recurrence and metastasis of B cell lymphoma."},"summary":{"aims":{"ja":"Bリンパ腫の有効な治療法開発に役立つ分子標的、および患者層別化のためのゲノム・エピゲノムマーカーの同定","en":"Identification of molecular targets for development effective therapeutic methods and genomic or epigenomic markers for stratification of B cell lymphoma patients."},"methods":{"ja":"Illumina HiSeq 2000を使用したExome解析","en":"Exome analysis by using of Illumina HiSeq 2000"},"targets":{"ja":"Bリンパ腫60症例の原発巣及び再発巣の腫瘍組織、非腫瘍組織","en":"147 normal, primary tumor, and recurrent tumor samples from 60 B cell lymphoma patients"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"Bリンパ腫：60症例\n（日本人）","en":"60 B cell lymphomas\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome）","en":"NGS\n(Exome)"}},"releaseNote":{"ja":"Bリンパ腫60症例の原発巣及び再発巣の腫瘍組織、非腫瘍組織より抽出したDNAを使用したExome解析の結果をFastqファイルにて提供する。\nSureSelect Human All Exon V4 ＋ lincRNA、SureSelect Human All Exon V5 ＋ lincRNAによりExon領域にしぼり、HiSeq 2000にて平均長100塩基を解読した（Paired-end）。","en":"DNAs extracted from 147 normal, primary tumor, and recurrent tumor tissues from 60 B cell lymphoma patients were used for the whole exome sequencing (fastq files).\nExons were narrowed down by using of SureSelect Human All Exon V4 + lincRNA, SureSelect Human All Exon V5 + lincRNA and read by Illumina HiSeq 2000 (paired-end: 100 bp)."},"dataProviders":[{"name":{"ja":"山口 俊晴","en":"Toshiharu Yamaguchi"},"organization":{"name":{"ja":"がん研究会有明病院","en":"The Cancer Institute Hospital of Japanese Foundation For Cancer Research (JFCR)"}}}],"researchProjects":[],"grants":[{"title":{"ja":"分子プロファイリングによる新規標的同定を通じた難治がん治療法開発（消化器がん及びリンパ腫の再発/転移に特徴的な遺伝子変異の同定）","en":"Development of the Intractable Cancer Therapies through the New Target Identification by the Molecular Profiling"},"agency":{"ja":"日本医療研究開発機構（AMED） 次世代がん研究シーズ戦略的育成プログラム（P-DIRECT）","en":"Project for Development of Innovative Research on Cancer Therapeutics (P-DIRECT), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP15cm0106060"]},{"title":{"ja":"先進的がん治療法開発のためのマルチオミック解析による基盤的基礎研究（患者腫瘍検体のゲノム・エピゲノム情報解析とデータベース構築）"},"agency":{"ja":"科学研究費助成事業（科学研究費補助金）（特定奨励費）","en":"JSPS KAKENHI"},"grantIds":null}],"relatedPublications":[],"datasets":["JGAD000087"],"controlledAccessUsers":[]}