{"id":"hum0132","version":1,"url":"https://humandbs.dbcls.jp/research/hum0132/v1","datePublished":"2018-09-07","versions":[{"version":1,"datePublished":"2018-09-07"}],"title":{"ja":"ベトナムにおけるダイオキシン関連疾患のゲノムシークエンス解析","en":"Identification of genetic alterations in Vietnamese individuals with elevated blood dioxin level"},"summary":{"aims":{"ja":"ベトナム戦争中にダイオキシンに暴露した兵士の子供に知的障害が見られることがある。知的障害の原因遺伝子を探索すること、および、ダイオキシンが突然変異に与える影響の検出を目的としている。","en":"Identification of genetic alterations in Vietnamese individuals with elevated blood dioxin level"},"methods":{"ja":"Illumina社のHiSeq 2500を用いた全ゲノムシークエンス","en":"Whole genome sequencing by HiSeq 2500 (Illumina)"},"targets":{"ja":"ダイオキシン暴露者（退役軍人）とその妻と子の9トリオ（計27名）","en":"Nine trios of the father exposed to dioxin for a few years and his wife and child with mental retardation (total 27 individuals)"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"ダイオキシン暴露者（退役軍人）とその妻と知的障害を持つ子の9トリオ（計27名）\n（ベトナム人）","en":"9 trios of the father exposed to dioxin and his wife and child with mental retardation (total 27 individuals)\n(Vietnamese)"},"typeOfData":{"ja":"NGS\n（WGS）","en":"NGS\n(WGS)"}},"releaseNote":{"ja":"ベトナム戦争中にダイオキシンに暴露された兵士、妻、知的障害を持つ子（9トリオ：計27名）の末梢血から抽出したDNAを使用した全ゲノム解析の結果をfastqファイルにて提供する。Illumina [HiSeq 2500]にて平均長101塩基または93塩基を解読した（Paired-end）。","en":"DNAs extracted from peripheral blood cells from nine trios of the Vietnamese People's Army exposed to dioxin and his wife and child with mental retardation were used for a whole genome sequencing analysis (fastq). Sequencing was performed by Illumina [HiSeq 2500] (Paired-end: 101 bp or 93 bp)."},"dataProviders":[{"name":{"ja":"中川 英刀","en":"Hidewaki Nakagawa"},"organization":{"name":{"ja":"理化学研究所・統合生命医科学研究センター・ゲノムシーケンス解析チーム","en":"Laboratory of Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences"}}}],"researchProjects":[{"name":{"ja":"ベトナム人トリオゲノムプロジェクト","en":"Vietnamese trio sequencing project"},"url":{"ja":null,"en":null}}],"grants":[{"title":{"ja":"血中ダイオキシンレベルが上昇しているベトナム人における遺伝子変異の同定","en":"Identification of genetic alterations in Vietnamese individuals with elevated blood dioxin level"},"agency":{"ja":"Scientific Program KHCN-33/11-15, the Ministry of Natural Resources and Environment (Vietnam)","en":"Scientific Program KHCN-33/11-15, the Ministry of Natural Resources and Environment (Vietnam)"},"grantIds":["KHCN-33.06/11-15"]},{"title":{"ja":"血中ダイオキシンレベルが上昇しているベトナム人における遺伝子変異の同定","en":"Identification of genetic alterations in Vietnamese individuals with elevated blood dioxin level"},"agency":{"ja":"the Ministry of Science and Technology (Vietnam)","en":"the Ministry of Science and Technology (Vietnam)"},"grantIds":["DTDL.CN-05/15"]}],"relatedPublications":[{"title":"Whole genome sequencing and mutation rate analysis of trios with paternal dioxin exposure.","doi":"https://doi.org/10.1002/humu.23585","datasets":["JGAD000206"]}],"datasets":["JGAD000206"],"controlledAccessUsers":[]}