{"id":"hum0127","secondaryIds":[],"version":1,"url":"https://humandbs.dbcls.jp/research/hum0127/v1","datePublished":"2020-04-14","versions":[{"version":1,"datePublished":"2020-04-14"},{"version":2,"datePublished":"2021-03-08"},{"version":3,"datePublished":"2024-01-22"},{"version":4,"datePublished":"2024-07-10"}],"title":{"ja":"マルチオーミクス解析を用いたがん患者評価に基づく個別化治療と新技術開発に関する研究ープロジェクトHOPE（High-tech Omics-based Patients Evaluation）for Cancer Therapyー","en":"Implementation of individualized medicine for cancer patients by multiomics-based analyses - the Project HOPE (High-tech Omics-based Patients Evaluation) for Cancer Therapy"},"summary":{"aims":{"ja":"腫瘍組織におけるPOLE遺伝子領域の変異の探索、および、がんの発生や進展過程に関与すると考えられる遺伝子内に高頻度に存在する変異を探索することで、分子生物学的特徴を検出し、新たながん診療技術の開発を目指す","en":"To clarify molecular biological features and develop new cancer treatments by searching for mutations in the POLE gene region in tumor tissues and the ones frequently present in genes involved in the development and progression of cancers"},"methods":{"ja":"末梢血の白血球（非腫瘍組織）および手術摘出組織（腫瘍組織）から抽出したDNAを対象としたWhole Exome sequencing","en":"DNAs extracted from peripheral blood cells (non-tumor tissues) and tumor tissues are analyzed by whole-exome sequencing"},"targets":{"ja":"いずれかのがんを発症し、静岡がんセンター病院において摘出手術を受けた2042症例のうち、POLE遺伝子内に変異を持ち、かつ、がん関連変異を高頻度で保有する症例","en":"91 hypermutated solid tumors that obtained from patients who take surgeries to remove tumor tissues at the Shizuoka Cancer Center Hospital"},"url":{"ja":[{"url":"https://www.scchr.jp/project-hope.html","text":"https://www.scchr.jp/project-hope.html"}],"en":[{"url":"https://www.scchr.jp/en/institute/projecthope.html","text":"https://www.scchr.jp/en/institute/projecthope.html"}]}},"listingSummary":{},"releaseNote":{"ja":"静岡がんセンター病院にて手術を受けたがん患者2042例のうち、POLE遺伝子領域内の変異、および、がん関連遺伝子内に高頻度で変異を持つ（高頻度遺伝子変異）91症例を対象とし、手術摘出組織（腫瘍組織）ならびに末梢血の白血球（非腫瘍組織）から抽出したDNAを用いたExome解析を実施。腫瘍組織と非腫瘍組織の塩基配列を比較し、腫瘍特異的な変異情報を提供する（vcf）。配列の解読にはIon Proton（Thermo Fisher Scientific）を用いた。","en":"DNAs extracted from blood cells (non-tumor tissues) and surgically dissected tumor tissues from 91 cancer patients with hypermutator tumors harborig POLE mutations were used for whole exome sequencing analysis. Variant information only in the tumor tissues was provided (vcf files). Sequencing were performed using Ion Proton (Thermo Fisher Scientific)."},"dataProviders":[{"name":{"ja":"山口 建","en":"Ken Yamaguchi"},"organization":{"name":{"ja":"静岡県立静岡がんセンター","en":"Shizuoka Cancer Center"}}}],"researchProjects":[{"name":{"ja":"プロジェクトHOPE （High-tech Omics-based Patient Evaluation）（がんのマルチオミクス解析）/ 静岡がんセンター","en":"Project HOPE (High-tech Omics-based Patient Evaluation) / Shizuoka Cancer Center"},"url":{"ja":[{"url":"https://www.scchr.jp/project-hope.html","text":"https://www.scchr.jp/project-hope.html"}],"en":[{"url":"https://www.scchr.jp/en/institute/projecthope.html","text":"https://www.scchr.jp/en/institute/projecthope.html"}]}}],"grants":[],"relatedPublications":[{"title":"Implementation of individualized medicine for cancer patients by multiomics-based analyses-the Project HOPE-","doi":"https://doi.org/10.2220/biomedres.35.407","datasets":null},{"title":"Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations","doi":"https://doi.org/10.1038/s41598-018-26967-4","datasets":["JGAD000141"]}],"datasets":["JGAD000141"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"万代 昌紀","en":"Masaki Mandai"},"affiliation":{"ja":"婦人科学産科学教室, 京都大学医学部医学研究科","en":"department of Gynecology and Obstetrics, Kyoto University Faculty of Medicene"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"多様な臨床情報を考慮した婦人科悪性腫瘍患者のオミックス解析（全ゲノム・全トランスクリプトーム・プロテオーム・メタボローム解析）による個別化治療の探索","en":"Integrated analyses of omics (genomics, transcriptomics, proteomics and metabolomics) associated with clinical variables for developing indivisualizedtreatment in gynecological malignancy"},"periodStart":"2018-10-04","periodEnd":"2025-04-14","datasets":["JGAD000141","JGAD000380"]},{"principalInvestigator":{"ja":"三森 功士","en":"Koshi Mimori"},"affiliation":{"ja":"外科, 九州大学病院別府病院","en":"Department of Surgery, Kyushu University Beppu Hospital"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"トランスオミクス解析による日本人乳癌の分子的特徴の解明","en":"Transomic analysis of molecular characterization of Japanese breast cancer"},"periodStart":"2021-06-01","periodEnd":"2025-08-05","datasets":["JGAD000141","JGAD000380"]},{"principalInvestigator":{"ja":"松村 謙臣","en":"Noriomi Matsumura"},"affiliation":{"ja":"産科婦人科学教室, 近畿大学医学部","en":"Obstetrics and Gynecology, Kindai University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"JGOG3017-TR1：エクソームシークエンスデータを有する卵巣明細胞癌のRNAseq解析","en":"Integrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR1"},"periodStart":"2024-10-15","periodEnd":"2027-12-31","datasets":["JGAD000141","JGAD000380","JGAD000733","JGAD000848"]},{"principalInvestigator":{"ja":"山口 建","en":"Ken Yamaguchi"},"affiliation":{"ja":"婦人科学産婦人科学教室, 京都大学","en":"Gynecology and Obstetrics, Kyoto University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"JGOG3017-TR1：エクソームシークエンスデータを有する卵巣明細胞癌のRNAseq解析","en":"Integrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR1"},"periodStart":"2024-10-22","periodEnd":"2027-12-31","datasets":["JGAD000848"]}]}