{"id":"hum0124","version":1,"url":"https://humandbs.dbcls.jp/research/hum0124/v1","datePublished":"2018-04-06","versions":[{"version":1,"datePublished":"2018-04-06"}],"title":{"ja":"ヒト上皮成長因子受容体（EGFR）遺伝子変異をもつ肺癌家系における肺癌発癌関連遺伝子同定に関する研究","en":"Study for exome sequencing in familial epidermal growth factor receptor-mutant lung cancer"},"summary":{"aims":{"ja":"ヒト上皮成長因子受容体（epidermal growth factor receptor：EGFR）遺伝子変異をもつ肺がん発癌関連遺伝子同定","en":"Identification of the genes associated with epidermal growth factor receptor (EGFR)-mutant lung cancer"},"methods":{"ja":"エクソーム解析","en":"exome sequencing"},"targets":{"ja":"EGFR遺伝子変異をもつ肺がん症例","en":"lung cancer patients with EGFR-mutants"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"EGFR遺伝子変異をもつ肺癌：3症例（1家系）\n（日本人）","en":"3 EGFR-mutant lung cancers\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome）","en":"NGS\n(Exome)"}},"releaseNote":{"ja":"ヒト上皮成長因子受容体遺伝子（EGFR）変異をもつ肺がん3症例（1家系）の末梢血より抽出したDNAを使用したExome解析の結果をbamファイルにて提供する。\nSureSelect Target Enrichment System Human All Exon V2によりExon領域にしぼり、Illumina HiSeq 2000にて平均長50塩基を解読した（Single-end）。","en":"DNAs extracted from peripheral blood cells from 3 EGFR-mutant lung cancer patients were used for the whole exome sequencing (bam files).\nExons were narrowed down by using of SureSelect Target Enrichment System Human All Exon V2 and read by Illumina HiSeq 2000 (single-end: 50 bp)."},"dataProviders":[{"name":{"ja":"菊地 利明","en":"Toshiaki Kikuchi"},"organization":{"name":{"ja":"新潟大学大学院 医歯学総合研究科","en":"Niigata University Graduate School of Medical and Dental Sciences"}}}],"researchProjects":[{"name":{"ja":"呼吸器･感染症内科学分野","en":"Department of Respiratory Medicine and Infectious Diseases"},"url":{"ja":[{"url":"https://www.med.niigata-u.ac.jp/resp/welcome.html","text":"https://www.med.niigata-u.ac.jp/resp/welcome.html"}],"en":null}}],"grants":[{"title":{"ja":"EGFR（上皮成長因子受容体）遺伝子変異陽性肺がんの遺伝子学的発がん機構の解明","en":"Genetic background on carcinogenic mechanisms of EGFR-mutant lung cancer"},"agency":{"ja":"日本医療研究開発機構（AMED） 次世代がん研究シーズ戦略的育成プログラム（P-DIRECT）","en":"Project for Development of Innovative Research on Cancer Therapeutics (P-DIRECT), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP15cm0106073"]},{"title":{"ja":"EGFR（上皮成長因子受容体）遺伝子変異陽性肺癌の分子遺伝学的発生母地の解明","en":"Molecular genetics of EGFR-mutant lung cancer"},"agency":{"ja":"科学研究費助成事業 挑戦的萌芽研究","en":"KAKENHI Grant-in-Aid for challenging Exploratory Research"},"grantIds":["24659399"]}],"relatedPublications":[{"title":"Exome sequencing deciphers a germline MET mutation in familial epidermal growth factor receptor-mutant lung cancer.","doi":"https://doi.org/10.1111/cas.13233","datasets":["JGAD000140"]}],"datasets":["JGAD000140"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"中岡 博史","en":"Hirofumi Nakaoka"},"affiliation":{"ja":"腫瘍ゲノム研究部, 公益財団法人佐々木研究所","en":"Department of Cancer Genome Research, Sasaki Institute"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"肺がん遺伝子解析研究","en":"Genetic analysis of lung cancer"},"periodStart":"2022-08-17","periodEnd":"2026-07-23","datasets":["JGAD000140"]}]}