{"id":"hum0119","version":1,"url":"https://humandbs.dbcls.jp/research/hum0119/v1","datePublished":"2019-01-31","versions":[{"version":1,"datePublished":"2019-01-31"}],"title":{"ja":"NASHの発症、進展を規定するメカニズム解析","en":"Analysis for mechanism of onset and progress for NASH"},"summary":{"aims":{"ja":"非アルコール性肝疾患（nonalcoholic fatty liver disease：NAFLD）、非アルコール性肝炎（nonalcoholic steatohepatitis：NASH）、NASH由来肝がん（NASH-HCC）関連遺伝因子の探索","en":"Discovery of genetic factors for NAFLD, NASH and NASH derived hepatocellular carcinoma"},"methods":{"ja":"SNPアレイによるゲノムスキャン","en":"Genome scan by SNP array"},"targets":{"ja":"NAFLD（Matteoni Type 1 and 2）：264症例、NASH（Matteoni Type 3 and 4）：580症例、NASH-HCC：58症例、対照群：7672名","en":"NAFLD patients (include 580 NASH and 58 NASH-HCC) : 902, controls : 7672"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"ゲノムワイド関連","en":"Genome-wide association"},"targets":{"ja":"NAFLD患者：902症例\n対照健常者：7672名\n（日本人）","en":"902 NAFLDs\n7672 healty controls\n(Japanese)"},"typeOfData":{"ja":"SNP-chip","en":"SNP-chip"}},"releaseNote":{"ja":"大阪府立吹田病院「非アルコール性脂肪性肝疾患の病態解明と診断法の開発に関する研究」において収集した非アルコール性肝疾患（NAFLD）：902症例（NAFLD群：264名、非アルコール性脂肪肝炎（NASH）群：580名、NASHから肝がんを発症した患者群：58名）および、「ながはま0次コホート健診」および愛知県がんセンターの「初診患者を対象にしたがん遺伝子多型と環境要因の交互作用の研究」において収集した健常者：7672名（ながはま：4653名、愛知がんセンター：3019名）、計8574名の末梢血から抽出したDNAを用いてSNPアレイによるGenotypingを実施し（Illumina [Human610-Quad BeadChip、HumanCoreExome BeadChip、HumanOmni2.5-Quad BeadChip]）、GWASを行った結果（各群のカウント情報と統計解析結果）を提供する（xlsx）。","en":"DNAs extracted from peripheral blood cells of 902 NAFLD patients (264 NAFLDs, 580 NASHs, and 58 NASH-HCCs) and 7672 healthy controls were genotyped by using of Illumina [Human610-Quad BeadChip, HumanCoreExome BeadChip, HumanOmni2.5-Quad BeadChip] and genome-wide association studies wrer performed (xlsx file)."},"dataProviders":[{"name":{"ja":"松田 文彦","en":"Fumihiko Matsuda"},"organization":{"name":{"ja":"京都大学大学院医学研究科附属ゲノム医学センター","en":"Center for Genomic Medicine, Kyoto University Graduate School of Medicine"}}}],"researchProjects":[],"grants":[{"title":{"ja":"非アルコール性脂肪性肝疾患の病態解明と診断法、治療法の開発に関する研究","en":"Research and development of pathophysiology, diagnostic tool and treatment in nonalcoholic fatty liver disease"},"agency":{"ja":"厚生労働科学研究費補助金 肝炎等克服緊急対策研究事業","en":"Health and Labour Sciences Research Grant for Research on Hepatitis"},"grantIds":["H20-Hepatitis-general-008"]}],"relatedPublications":[{"title":"Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers","doi":"https://doi.org/10.1371/journal.pone.0185490","datasets":["JGAD000137"]}],"datasets":["JGAD000137"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"竹原 徹郎","en":"Tetsuo Takehara"},"affiliation":{"ja":"消化器内科学, 大阪大学大学院医学系研究科","en":"Gastroenterology and Hepatology, Osaka University, Graduate School of Medicine"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"慢性肝疾患の病態進展を予測するバイオマーカーとなる遺伝子多型・変異の探索","en":"A study of gene polymorphism and mutation to predict the progression of chronic liver disease"},"periodStart":"2021-03-18","periodEnd":"2026-08-31","datasets":["JGAD000137"]}]}