{"id":"hum0117","version":1,"url":"https://humandbs.dbcls.jp/research/hum0117/v1","datePublished":"2017-12-11","versions":[{"version":1,"datePublished":"2017-12-11"}],"title":{"ja":"神経変性疾患のエピジェネティクス解析","en":"Epigenetics analysis of neurodegenerative diseases"},"summary":{"aims":{"ja":"アルツハイマー病における神経細胞特異的メチル化変化の検出","en":"Detecting Neuron-specifc methylation changes in Alzheimer's disease brain"},"methods":{"ja":"Illumina Infinium® Human Methylation 450K BeadChip","en":"Illumina Infinium® Human Methylation 450K BeadChip"},"targets":{"ja":"アルツハイマー病30症例、対照健常者30名","en":"30 Alzheimer's diseasepatients and 30 healthy controls"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"メチル化","en":"Methylation profiling"},"targets":{"ja":"アルツハイマー病：30症例\n対照健常者：30名\n（日本人）","en":"30 Alzheimer's disease patients\n30 healty controls\n(Japanese)"},"typeOfData":{"ja":"メチル化アレイ","en":"Methylation array"}},"releaseNote":{"ja":"アルツハイマー病患者および対照健常者の剖検脳組織から抽出した神経細胞核由来のDNAを対象とし、Illumina Infinium® Human Methylation 450K BeadChipにてメチル化解析を行った結果をidat形式にて提供する。","en":"DNAs extracted from autopsied brain tissues of Alzheimer's disease patients and healthy controls were used for methylation analysis with Illumina Infinium® Human Methylation 450K BeadChip (idat format)."},"dataProviders":[{"name":{"ja":"岩田 淳","en":"Atsushi Iwata"},"organization":{"name":{"ja":"東京大学医学部附属病院 神経内科","en":"The University of Tokyo Hospital"}}}],"researchProjects":[],"grants":[{"title":{"ja":"変性性認知症の新規病態解明のためのneuro-epigenetics方法論の応用","en":"A novel neuro-epigenetic approach to the pathogenic mechanism of the neurodegenerative dementia diseases"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["16H05319"]},{"title":{"ja":"新規アルツハイマー病モデルの開発とDNA傷害の解析","en":"Analysis of DNA damage mechanism in the novel cellular and mouse model of Alzheimer's disease"},"agency":{"ja":"科学研究費助成事業 若手研究（B）","en":"KAKENHI Grant-in-Aid for Young Scientists (B)"},"grantIds":["17K16113"]},{"title":{"ja":"孤発性アルツハイマー病アミロイド蓄積の原因に即した治療薬と診断用バイオマーカーの開発","en":"Development of a new disease-modifying therapy and early diagnostic method of Alzheimer's disease based on a cause of amyloid deposition observed in sporadic type"},"agency":{"ja":"日本医療研究開発機構（AMED） 脳科学研究戦略推進プログラム","en":"Strategic Research Program for Brain Sciences, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP16dm0107069"]}],"relatedPublications":[{"title":"Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.","doi":"https://doi.org/10.1073/pnas.1707151114","datasets":["JGAD000136"]}],"datasets":["JGAD000136"],"controlledAccessUsers":[]}