{"id":"hum0114","version":2,"url":"https://humandbs.dbcls.jp/research/hum0114/v2","datePublished":"2019-04-12","versions":[{"version":1,"datePublished":"2017-12-18"},{"version":2,"datePublished":"2019-04-12"},{"version":3,"datePublished":"2021-08-10"}],"title":{"ja":"日本人由来B細胞株DNAのゲノムデータを用いた遺伝統計解析手法の研究","en":"Research on statistical genetics using B cell lines of Japanese ancestry"},"summary":{"aims":{"ja":"日本人細胞株由来のゲノムデータを用いた遺伝統計解析の実施","en":"Analysis of statistical genetics using cell line genotype data of Japanese ancestry"},"methods":{"ja":"ゲノムワイド関連解析の実施（乾癬）、および、HLA領域に対するTarget capture sequenceの実施、ならびに、KIR領域におけるgenotype imputation reference panelの構築","en":"Genome-wide association study for psoriasis, Target capture sequence for HLA regioin, Construction of imputation reference panel of the KIR region"},"targets":{"ja":"日本人細胞株由来ゲノム","en":"Cell line genotype data of Japanese ancestry"},"url":{"ja":null,"en":null}},"listingSummary":{},"releaseNote":{"ja":"日本人細胞株（JBIC細胞株）560検体から抽出したDNAを使用し、HLA領域を対象としたTarget capture sequenceを実施した結果をfastqファイルにて提供する。","en":"DNAs extracted from cell lines of Japanese population (560 samples) were used for a target capture sequencing analysis for HLA region (fastq file)."},"dataProviders":[{"name":{"ja":"岡田 随象","en":"Yukinori Okada"},"organization":{"name":{"ja":"大阪大学大学院医学系研究科 遺伝統計学","en":"Department of Statistical Genetics, Osaka University Graduate School of Medicine"}}}],"researchProjects":[],"grants":[{"title":{"ja":"遺伝統計学とビッグデータの邂逅がもたらす新たながんゲノム創薬","en":"Cancer drug discovery based on statistical genetics and big data"},"agency":{"ja":"科学研究費助成事業 新学術領域研究","en":"KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas"},"grantIds":["15H05911"]},{"title":{"ja":"HLA imputation法を用いた自己免疫疾患のバイオマーカーの同定","en":"Identification of autoimmune disease biomarkers using HLA imputation"},"agency":{"ja":"科学研究費助成事業 若手研究（A）","en":"KAKENHI Grant-in-Aid for Young Scientists (A)"},"grantIds":["15H05670"]},{"title":{"ja":"遺伝統計学に基づく日本人集団のゲノム個別化医療の実装","en":"Implementation of genomic prediction medicine based on statistical genetics"},"agency":{"ja":"日本医療研究開発機構（AMED） ゲノム医療実現推進プラットフォーム事業（先端ゲノム研究開発）","en":"Advanced Genome Research and Bioinformatics Study to Facilitate Medical Innovation (GRIFIN), Platform Program for Promotion of Genome Medicine, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP21km0405211"]}],"relatedPublications":[{"title":"Variants at HLA-A, HLA-C, and HLA-DQB1 confer risk of psoriasis vulgaris in Japanese","doi":"https://doi.org/10.1016/j.jid.2017.10.001","datasets":["NHA000059"]},{"title":"Genetic and phenotypic landscape of the major histocompatibilty complex region in the Japanese population.","doi":"https://doi.org/10.1038/s41588-018-0336-0","datasets":["DRA007411"]}],"datasets":["NHA000059","DRA007411"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"莚田 泰誠","en":"Taisei Mushiroda"},"affiliation":{"ja":"ファーマコゲノミクス研究チーム, 理化学研究所　生命医科学研究センター","en":"RIKEN Center for Integrative Medical Sciences"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"小麦アレルギーの遺伝子多型解析","en":"SNP analysis of wheat allergy"},"periodStart":"2021-03-26","periodEnd":"2028-03-31","datasets":["JGAD000425"]},{"principalInvestigator":{"ja":"福永 航也","en":"Koya Fukunaga"},"affiliation":{"ja":"医薬安全科学部, 国立医薬品食品衛生研究所","en":"Medical safety science, National institute of health sciences"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"重篤な皮膚有害事象の診断・治療と遺伝子マーカーに関する研究","en":"Research on the diagnosis, treatment, and biomarkers for severe cutaneous adverse reactions"},"periodStart":"2023-02-10","periodEnd":"2026-03-02","datasets":["JGAD000425"]},{"principalInvestigator":{"ja":"福永 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