{"id":"hum0113","version":3,"url":"https://humandbs.dbcls.jp/research/hum0113/v3","datePublished":"2022-07-29","versions":[{"version":1,"datePublished":"2020-04-24"},{"version":2,"datePublished":"2021-07-30"},{"version":3,"datePublished":"2022-07-29"}],"title":{"ja":"パーキンソン病の代謝産物バイオマーカー創出およびその分子標的機構に基づく創薬シーズ同定","en":"Development of metabolite biomarkers of Parkinson's disease and identification of drug seeds from chemical screening based on the biomarkers"},"summary":{"aims":{"ja":"パーキンソン病（Parkinson's Disease: PD）のRNAバイオマーカーの同定","en":"Identification of RNA biomarkers in Parkinson's disease (PD) patients"},"methods":{"ja":"Transcriptome sequencing（CAGE-seq）","en":"Transcriptome sequencing (CAGE-seq)"},"targets":{"ja":"PD 39症例および神経疾患を持たない（non-PD）対照健常者20名の全血\nPARK2 変異を有するPD 2症例およびnon-PD対照健常者3名より樹立したiPS細胞由来神経細胞とiPS細胞由来神経幹細胞（Neuronal stem cell：NSC）のペア","en":"Whole blood samples from 39 PD patients and 20 non-PD (healthy) controls\niPS-derived neuron cells provided by 2 PD patients with PARK2 mutations and 3 non-PD (healthy) controls\niPS-derived neuronal stem cells (NSC) provided by 2 PD patients with PARK2 mutations and 3 non-PD (healthy) controls"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"転写開始点同定","en":"Transcription start site identification"},"targets":{"ja":"パーキンソン病：39症例、対照健常者：20名\niPS細胞由来神経細胞（パーキンソン病：3検体、対照健常者：3検体から樹立）\n（日本人）","en":"39 PD patients, 20 non-PD (healthy) contorols\niPS derived neurons: 3 PD samples and 3 controls\n(Japanese)"},"typeOfData":{"ja":"NGS\n（CAGE-seq）","en":"NGS\n(CAGE-seq)"}},"releaseNote":{"ja":"hum0113.v2のCAGEライブラリをHiSeq 2500（paired-end）で再シーケンスした。シーケンス結果をfastqファイルにて提供する。","en":"CAGE libraries in hum0113.v2 were resequenced with HiSeq 2500 (paired-end). Sequencing outputs are provided in fastq files."},"dataProviders":[{"name":{"ja":"ピエロ・カルニンチ","en":"Piero Carninci"},"organization":{"name":{"ja":"理化学研究所 生命医科学研究センター ゲノム機能医科学研究部門","en":"RIKEN Center for Integrative Medicine Science, Division of Genomic Medicine"}}}],"researchProjects":[],"grants":[{"title":{"ja":"パーキンソン病の代謝産物バイオマーカー創出およびその分子標的機構に基づく創薬シーズ同定","en":"Development of metabolite biomarker specific for Parkinson's disease and identification of drug seeds based on its molecular target"},"agency":{"ja":"日本医療研究開発機構 革新的先端研究開発支援事業（AMED-CREST）","en":"Core Research and Evolutional Science and Technology, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-CREST)"},"grantIds":["JP19gm0710011"]}],"relatedPublications":[{"title":"Multi-year whole-blood transcriptome data for the study of onset and progression of Parkinson's Disease","doi":"https://doi.org/10.1038/s41597-019-0022-9","datasets":["JGAD000129"]}],"datasets":["JGAD000129","JGAD000211","JGAD000429"],"controlledAccessUsers":[]}