{"id":"hum0108","version":1,"url":"https://humandbs.dbcls.jp/research/hum0108/v1","datePublished":"2017-06-26","versions":[{"version":1,"datePublished":"2017-06-26"}],"title":{"ja":"精神疾患発症にかかわる関連遺伝子の探索および解析","en":"Search for new susceptibility genetic factors associated with psychiatric disorders"},"summary":{"aims":{"ja":"パニック症に関わるDNAメチル化の探索","en":"Searching for DNA methylation sites associated with panic disorder"},"methods":{"ja":"メチル化アレイによりパニック症患者および健常者のゲノムワイドなメチル化率を取得後、ケース・コントロール解析を実施","en":"Epigenome-wide DNA methylation analysis using array technology and case-control analysis"},"targets":{"ja":"パニック症48症例、対照健常者48名（一卵性双生児不一致例を1組含む）","en":"Patients of panic disorder and healthy controls"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"メチル化","en":"Methylation profiling"},"targets":{"ja":"パニック症：48症例\n対照健常者：48名\n（日本人）","en":"48 panic disorder patients\n48 healthy controls\n(Japanese)"},"typeOfData":{"ja":"メチル化アレイ","en":"Methylation array"}},"releaseNote":{"ja":"パニック症患者および対照健常者の末梢血から抽出したDNAを対象としてIllumina Infinium® Human Methylation 450K BeadChipにてメチル化解析を行い、メチル化率のデータを用いた関連解析の結果をエクセルファイルにて提供する。","en":"DNAs extracted from peripheral blood cells of 48 panic disorder patients and 48 healthy control subjects were used for methylation analysis. Methylation levels, β values, were calculated from the values detected by IIllumina Infinium® Human Methylation 450K BeadChip (excel format)."},"dataProviders":[{"name":{"ja":"徳永 勝士","en":"Katsushi Tokunaga"},"organization":{"name":{"ja":"東京大学大学院 医学系研究科 国際保健学専攻 人類遺伝学教室","en":"Department of Human Genetics, Graduate School of Medicine, the University of Tokyo"}}}],"researchProjects":[],"grants":[{"title":{"ja":"パニック障害に関連する遺伝要因の探索","en":"Search for new susceptibility genetic factors associated with panic disorder"},"agency":{"ja":"科学研究費助成事業 特別研究員奨励費","en":"KAKENHI Grant-in-Aid for JSPS Research Fellows"},"grantIds":["15J04964"]},{"title":{"ja":"ゲノムワイド関連解析とDNAメチル化解析を統合したパニック障害候補遺伝子の探索","en":"Search for genetic factors associated with panic disorder by a combination analysis of GWAS and DNA methylation analysis"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["26461712"]},{"title":{"ja":"うつ病に関連する遺伝子およびそのメチル化と養育期環境の交互作用の解析","en":"An interaction analysis between 'Parental Care' and genetic or epigenetic factors associated with depression"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["25461723"]},{"title":{"ja":"全ゲノムDNAメチル化関連解析によるパニック障害候補遺伝部位の探索","en":"Genome-wide association analysis to identify new candidate genomic loci associated with panic disorder"},"agency":{"ja":"武田科学振興財団医学系研究奨励","en":"Takeda Science Foundation"},"grantIds":null}],"relatedPublications":[{"title":"Epigenome-wide association study of DNA methylation in panic disorder","doi":"https://doi.org/10.1186/s13148-016-0307-1","datasets":["JGAD000120"]}],"datasets":["JGAD000120"],"controlledAccessUsers":[{"principalInvestigator":{"en":"Brock Christensen"},"affiliation":{"en":"Department of Epidemiology, Geisel School of Medicine at Dartmouth"},"country":{"ja":"アメリカ合衆国 (ニューハンプシャー州)","en":"New Hampshire, United States"},"researchTitle":{"ja":"Immunomethylomic approach to investigat immune status in psychiartic conditions","en":"Immunomethylomic approach to investigat immune status in psychiartic conditions"},"periodStart":"2018-08-06","periodEnd":"2022-05-25","datasets":["JGAD000120"]}]}