{"id":"hum0086","version":2,"url":"https://humandbs.dbcls.jp/research/hum0086/v2","datePublished":"2017-12-26","versions":[{"version":1,"datePublished":"2017-09-25"},{"version":2,"datePublished":"2017-12-26"},{"version":3,"datePublished":"2018-06-26"}],"title":{"ja":"生殖発生にかかわる細胞のエピゲノム解析基盤研究","en":"Epigenomic analysis of the human placenta and endometrium constituting the fetal-maternal interface"},"summary":{"aims":{"ja":"国際ヒトエピゲノムコンソーシアム（The International Human Epigenome Consortium: IHEC）に参画し、日本人検体から得られた胎盤組織の高品質な標準エピゲノムプロファイルを取得し、データを広く公開し研究基盤形成に貢献する。","en":"As a member of the International Human Epigenome Consortium (IHEC), we obtain high-quality standard epigenome profiles of placenta tissue from Japanese donors, and open the data to public to promote basic research in human epigenome."},"methods":{"ja":"PBAT-seq、ChIP-seq、RNA-seq、small RNA-seq","en":"PBAT-seq, ChIP-seq, RNA-seq, and small RNA-seq"},"targets":{"ja":"胎盤（細胞性栄養膜細胞 [正常/CT、胎児発育不全/FGR-CT、妊娠高血圧症候群/PE-CT、18トリソミー/Tri-18-CT]、合胞体栄養膜細胞 [ST]、絨毛外栄養膜細胞 [EVT]、FemaleのCTから作製したヒト胎盤幹細胞 [TS]およびTSをST/EVTへ分化させた細胞、MaleのCTから作製したヒト胎盤幹細胞 [TS]およびTSをST/EVTへ分化させた細胞、絨毛間質細胞）、子宮内膜（間質細胞、腺上皮細胞）、全胞状奇胎","en":"placenta (cytotrophoblast [normal/CT, fetal growth restriction/FGR-CT, preeclampsia/PE-CT, trisomy 18/Tri-18-CT], syncytiotrophoblast [ST], extravillous trophoblast [EVT], trophoblast stem cells [TS] derived from female/male CT, ST differentiated from TS, EVT differentiated from TS, stroma), uterus (endometrium epithelial, stroma), hydatidiform mole"},"url":{"ja":null,"en":[{"url":"https://crest-ihec.jp/english/index.html","text":"https://crest-ihec.jp/english/index.html"}]}},"listingSummary":{},"dataProviders":[{"name":{"ja":"佐々木 裕之","en":"Hiroyuki Sasaki"},"organization":{"name":{"ja":"九州大学 生体防御医学研究所","en":"Medical Institute of Bioregulation, Kyushu University"}}}],"researchProjects":[{"name":{"ja":"革新的先端研究開発支援事業（AMED-CREST） 国際ヒトエピゲノムコンソーシアム（IHEC）佐々木チーム","en":"Core Research and Evolutional Science and Technology (CREST), International Human Epigenome Consortium (IHEC), Sasaki Team"},"url":{"ja":[{"url":"https://crest-ihec.jp/index.html","text":"https://crest-ihec.jp/index.html"}],"en":[{"url":"https://crest-ihec.jp/english/index.html","text":"https://crest-ihec.jp/english/index.html"}]}}],"grants":[{"title":{"ja":"「エピゲノム研究に基づく診断・治療へ向けた新技術の創出」領域","en":"Development of Fundamental Technologies for Diagnosis and Therapy Based upon Epigenome Analysis"},"agency":{"ja":"日本医療研究開発機構 革新的先端研究開発支援事業（AMED-CREST）","en":"Core Research and Evolutional Science and Technology, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-CREST)"},"grantIds":null}],"relatedPublications":[{"title":"The International Human Epigenome Consortium: A blueprint for scientific collaboration and discovery.","doi":"https://doi.org/10.1016/j.cell.2016.11.007","datasets":["JGAD000073"]},{"title":"Allele-specific methylome and transcriptome analysis reveals widespread imprinting in the human placenta","doi":"https://doi.org/10.1016/j.ajhg.2016.08.021","datasets":["JGAD000038"]},{"title":"Derivation of Human Trophoblast Stem Cells","doi":"https://doi.org/10.1016/j.stem.2017.11.004","datasets":["JGAD000073","JGAD000115","JGAD000121"]},{"title":"The microRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cells","doi":"https://doi.org/10.1038/s41467-022-30775-w","datasets":["JGAD000115","JGAD000121"]}],"datasets":["JGAD000073","JGAD000115"],"controlledAccessUsers":[{"principalInvestigator":{"en":"Nehemiah Alvarez"},"affiliation":{"en":"De Novo Genomics Corporation"},"country":{"ja":"アメリカ合衆国 (カンザス州)","en":"Kansas, United States"},"researchTitle":{"ja":"Evolutionary conservation of gene expression and epigenetic analysis of  trophoblast stem cells","en":"Evolutionary conservation of gene expression and epigenetic analysis of  trophoblast stem cells"},"periodStart":"2018-02-02","periodEnd":"2021-03-19","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"Michael Roberts"},"affiliation":{"en":"Animal Sciences/ Biochemistry, University of Missouri"},"country":{"ja":"アメリカ合衆国 (ミズーリ州)","en":"Missouri, United States"},"researchTitle":{"ja":"A comparative analysis of transcriptome data from placental cell line derived from anonymous placental cells","en":"A comparative analysis of transcriptome data from placental cell line derived from anonymous placental cells"},"periodStart":"2018-03-02","periodEnd":"2023-08-28","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"Guillaume Bourque"},"affiliation":{"en":"McGill University & Genome Quebec Innovation Center, McGill University"},"country":{"ja":"カナダ (ケベック州)","en":"Quebec, Canada"},"researchTitle":{"ja":"Epigenome Meta-Analysis Project (epiMAP)","en":"Epigenome Meta-Analysis Project (epiMAP)"},"periodStart":"2018-06-07","periodEnd":"2021-03-19","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"Martin Hirst"},"affiliation":{"en":"BC Cancer, part of the Provincial Health Services Authority"},"country":{"ja":"カナダ (ブリティッシュコロンビア州)","en":"British Columbia, Canada"},"researchTitle":{"ja":"Epigenomic analysis of human samples","en":"Epigenomic analysis of human samples"},"periodStart":"2018-08-06","periodEnd":"2022-09-05","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"Zhaobo Lin"},"affiliation":{"en":"School of Life Science and Technology, ShanghaiTech University"},"country":{"ja":"中国","en":"China"},"researchTitle":{"ja":"Comparison between reprogrammed and primary trophoblast stem cells","en":"Comparison between reprogrammed and primary trophoblast stem cells"},"periodStart":"2018-11-12","periodEnd":"2023-07-05","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"Zhigang Xue"},"affiliation":{"en":"School of Medicine and Life Science, Tongji University"},"country":{"ja":"中国","en":"China"},"researchTitle":{"ja":"Mechanism of cell programming and embryo-gamete original disease in human embryo development.","en":"Mechanism of cell programming and embryo-gamete original disease in human embryo development."},"periodStart":"2018-12-17","periodEnd":"2021-03-19","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"Todd Macfarlan"},"affiliation":{"en":"National Institute of Child Health and Human Development"},"country":{"ja":"アメリカ合衆国 (メリーランド州)","en":"Maryland, United States"},"researchTitle":{"ja":"Analysis of the public methylome, chromatin and transcription profiles for induced human trophoblast stem cells","en":"Analysis of the public methylome, chromatin and transcription profiles for induced human trophoblast stem cells"},"periodStart":"2018-12-17","periodEnd":"2019-09-04","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"William Yeung"},"affiliation":{"en":"Department of O&G, The University of Hong Kong"},"country":{"ja":"中国","en":"China"},"researchTitle":{"ja":"Derivation of human expanded potential stem cells (EPSCs) from human pre-implantation embryos","en":"Derivation of human expanded potential stem cells (EPSCs) from human pre-implantation embryos"},"periodStart":"2019-02-12","periodEnd":"2020-09-02","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"Amir Eden"},"affiliation":{"en":"Department of Cell & Developmental Biology , Institute of Life Sciences, The HebrewUniversity of Jerusalem"},"country":{"ja":"イスラエル","en":"Israel"},"researchTitle":{"ja":"Consequences of DNA hypomethylation- alternative promoters","en":"Consequences of DNA hypomethylation- alternative promoters"},"periodStart":"2019-05-07","periodEnd":"2023-07-13","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"AUSTIN SMITH"},"affiliation":{"en":"Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge"},"country":{"ja":"イギリス","en":"United Kingdom"},"researchTitle":{"ja":"Comparison of trophoblast stem cell cultures","en":"Comparison of trophoblast stem cell cultures"},"periodStart":"2019-08-19","periodEnd":"2023-07-25","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"Thorold Theunissen"},"affiliation":{"en":"Washington University School of Medicine in St. Louis"},"country":{"ja":"アメリカ合衆国 (ミズーリ州)","en":"Missouri, United States"},"researchTitle":{"ja":"Assessment of trophoblast fates derived from human pluripotent stem cells","en":"Assessment of trophoblast fates derived from human pluripotent stem cells"},"periodStart":"2019-12-10","periodEnd":"2023-07-05","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"Hu Li"},"affiliation":{"en":"Department of Histoembryology, Genetics and Developmental Biology, Shanghai JiaoTong University School of Medicine"},"country":{"ja":"中国","en":"China"},"researchTitle":{"ja":"Derivation of Human induced Trophoblast Stem Cells from Embryonic Stem Cells","en":"Derivation of Human induced Trophoblast Stem Cells from Embryonic Stem Cells"},"periodStart":"2020-01-15","periodEnd":"2024-01-30","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"ja":"大串 雅俊","en":"Masatoshi Ohgushi"},"affiliation":{"ja":"発生システム制御分野, 京都大学ウイルス・再生位科学研究所","en":"Lab. of Developmental System, Instutute for Frontier Life and Medical Sciences, Kyoto University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"ヒト多能性幹細胞の分化ポテンシャルに関する研究","en":"Exploring differentiaton potential of human pluripotent stem cells"},"periodStart":"2020-03-19","periodEnd":"2023-09-21","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"Anton Wellstein"},"affiliation":{"en":"Department of Oncology, Georgetown University School of Medicine"},"country":{"ja":"アメリカ合衆国","en":"United States"},"researchTitle":{"ja":"Biomarkers to evaluate immune related adverse events (irAEs) due to treatment with immune checkpoint inhibitors (ICIs)","en":"Biomarkers to evaluate immune related adverse events (irAEs) due to treatment with immune checkpoint inhibitors (ICIs)"},"periodStart":"2022-03-03","periodEnd":"2020-09-01","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"Kichoon Lee"},"affiliation":{},"country":{"ja":"アメリカ合衆国","en":"United States"},"researchTitle":{"en":"Access to the National Bioscience Database Center"},"periodStart":"2021-05-31","periodEnd":"2024-12-31","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"Jonghwan Kim"},"affiliation":{"en":"Department of Molecular Biosciences, University of Texas at Austin"},"country":{"ja":"アメリカ合衆国 (テキサス州)","en":"Texas, United States"},"researchTitle":{"en":"Establishment of human trophoblast stem-like cells derived from human induced pluripotent stem cells for studying human placental development"},"periodStart":"2021-05-31","periodEnd":"2023-07-05","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"ja":"秦 健一郎","en":"Kenichiro Hata"},"affiliation":{"ja":"周産期病態研究部, 国立成育医療研究センター","en":"Department of Maternal-Fetal Biology, National Center for Child Health and Development"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"胎児発育異常の遺伝子・ゲノム解析","en":"Genetic and genomic analysis of fetal developmental abnormalities"},"periodStart":"2021-06-17","periodEnd":"2022-03-31","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"Danny Leung"},"affiliation":{"en":"Division of Life Science, The Hong Kong University of Science and Technology"},"country":{"ja":"香港","en":"Hong Kong"},"researchTitle":{"en":"Defining the transcriptional regulatory roles of retrotransposons in human placenta cells."},"periodStart":"2021-08-11","periodEnd":"2027-05-28","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"ja":"秦 健一郎","en":"Kenichiro Hata"},"affiliation":{"ja":"周産期病態研究部, 国立成育医療研究センター","en":"Department of Maternal-Fetal Biology, National Center for Child Health and Development"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"胎児発育異常の遺伝子・ゲノム解析","en":"Genetic and genomic analysis of fetal developmental abnormalities"},"periodStart":"2022-01-11","periodEnd":"2022-03-31","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"Gianluca Ursini"},"affiliation":{"en":"Lieber Institute for Brain Development, Johns Hopkins University School of Medicine"},"country":{"ja":"アメリカ合衆国 (メリーランド州)","en":"Maryland, United States"},"researchTitle":{"en":"Analysis of the transcriptional profile of Human Trophoblast Stem Cells"},"periodStart":"2022-04-26","periodEnd":"2026-12-31","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"Ming-an Sun"},"affiliation":{"en":"College of Veterinary Medicine, Yangzhou University"},"country":{"ja":"中国","en":"China"},"researchTitle":{"en":"The activation and function of endogenous retroviruses in mammalian placentae"},"periodStart":"2022-06-23","periodEnd":"2025-01-10","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"Wilfried Haerty"},"affiliation":{"en":"Research Faculty, Earlham Institute"},"country":{"ja":"イギリス","en":"United Kingdom"},"researchTitle":{"en":"Understanding epigenetic drift in a transient reproductive tissue - defining the effects on gestation ageing and cell identity within the placenta"},"periodStart":"2023-04-12","periodEnd":"2025-02-06","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"en":"Paul Robson"},"affiliation":{"en":"Genomic Medicine, The Jackson Laboratory"},"country":{"ja":"アメリカ合衆国 (コネチカット州)","en":"Connecticut, United States"},"researchTitle":{"en":"Modeling extra-embryonic mesoderm lineage development with human induced pluripotent stem cells "},"periodStart":"2024-02-08","periodEnd":"2026-12-26","datasets":["JGAD000073","JGAD000115"]},{"principalInvestigator":{"ja":"依馬 正次","en":"Masatsugu Ema"},"affiliation":{"ja":"幹細胞・ヒト疾患モデル研究分野, 滋賀医科大学　動物生命科学研究センター","en":"Department of Stem Cells and Human Disease Models, Shiga University of Medical Science, Research Center for Animal Life Science"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"ヒト胎盤からの栄養膜幹細胞の単離と性状解析","en":"Isolation and characterization of trophoblast stem cells from human placenta"},"periodStart":"2024-08-19","periodEnd":"2029-08-31","datasets":["JGAD000073","JGAD000115"]}]}