{"id":"hum0085","version":1,"url":"https://humandbs.dbcls.jp/research/hum0085/v1","datePublished":"2017-10-16","versions":[{"version":1,"datePublished":"2017-10-16"},{"version":2,"datePublished":"2018-09-25"}],"title":{"ja":"胸腹部腫瘍の長期治療成績に関する分子生物学的研究 / 環境因子が関与する腫瘍のゲノム解析","en":"Molecular biological research affecting on long-term treatment to malignant tumors derived from the chest or abdomen / Genomic analysis of environment-associated tumors"},"summary":{"aims":{"ja":"悪性中皮腫はアスベスト曝露が主要因となる極めて予後不良の悪性腫瘍である。その治療成績の向上のためには腫瘍組織における変異やゲノム構造異常等、分子生物学的特性を把握し、早期診断、治療標的分子の同定が必要である。近年の家族性悪性中皮腫の報告からも、遺伝的背景と易罹患性との関連研究も重要である。悪性中皮腫の罹患者数が他の腫瘍に比べて少ないため、解析対象は日本人だけでなく、悪性中皮腫罹患者数が多い米国人やトルコ人検体も解析し、人種にかかわらず悪性中皮腫患者に共通するゲノム特性を抽出することを目的とする。","en":"Malignant mesotheliomas (MMs) are highly aggressive adult malignancies and exposure to asbestos is the major factor involved in MM pathogenesis. It is desirable for a better understanding of the molecular pathogenesis of MM will lead to more specific and effective targeted therapies. It is reported that germline mutation in a specific gene associates familial MMs. New candidate markers to determine a subject's predisposition to MM and for early detection need to be identified. Analysis of genomic DNA from MM tumors and reference peripheral blood cells from Japan, USA, and Turkey's patients are ongoing to find the common genomic characters beyond race."},"methods":{"ja":"3p21を対象とした高解像度アレイCGH、および、次世代シーケンス解析（Whole Genome Sequencing [WGS]、Target Capture Sequencing、Whole Exome Sequencing）","en":"Array CGH for chromosome 3p21, Whole Genome Sequencing (NGS), Target Capture Sequencing (NGS) and Whole Exome Sequencing (NGS)"},"targets":{"ja":"悪性中皮腫患者の腫瘍組織および末梢血（非腫瘍組織）から抽出したDNA","en":"Genomic DNA from MM tumors and reference peripheral blood cells"},"url":{"ja":null,"en":null}},"listingSummary":{},"releaseNote":{"ja":"悪性中皮腫32症例（日本人：9症例、米国人：23症例）の腫瘍組織および末梢血（非腫瘍組織）から抽出したDNAを使用したアレイCGH解析、WGS解析、およびターゲットキャプチャーシーケンス解析の結果をテキストおよびFastqファイルにて提供する。","en":"gDNA extracted from malignant mesothelioma tumors and peripheral blood cells (non-tumor) obtained from 9 Japanese and 23 American malignant mesothelioma patients were used for Array CGH , whole genome sequencing analysis and target capture sequencing analysis (text and fastq files)."},"dataProviders":[{"name":{"ja":"大村谷 昌樹","en":"Masaki Ohmuraya"},"organization":{"name":{"ja":"兵庫医科大学 遺伝学","en":"Department of Genetics, Hyogo College of Medicine"}}}],"researchProjects":[],"grants":[{"title":{"ja":"日本人悪性中皮腫に高頻度で見出された3p領域欠損の機能解析と診断への応用","en":"Deletion of the 3p region in malignant mesothelioma cells derived from Japanese patients"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["24590715"]},{"title":{"ja":"日本人悪性中皮腫におけるゲノム不安定性に基づく治療戦略の基礎的検討","en":"Basic research about the medical treatment based on the genomic instability of malignant mesothelioma from Japanese patients"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["15K08658"]},{"title":{"ja":"環境癌における3p21領域ゲノム構造異常の詳細解析","en":"Analysis of genome structural abnormalities of 3p21 in environment-associated cancers"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["25460710"]},{"title":{"ja":"悪性中皮腫の易罹患性を生殖細胞系列ゲノムで診断する方法の考案","en":"Search about germline genetic predisposition to malignant mesothelioma"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["26460689"]},{"title":{"ja":"悪性中皮腫易罹患性に寄与するゲノム多型/変異を探索する国際共同研究-人種やアスベスト暴露多寡に依存しない罹患寄与遺伝子の探索-","en":"International collaborative research to search for the predisposition genes to malignant mesothelioma -the predisposition genes which are not confined to a particular race and asbestos exposure condition"},"agency":{"ja":"Grant-in-Aid for Researchers from Hyogo College of Medicine","en":"Grant-in-Aid for Researchers from Hyogo College of Medicine"},"grantIds":["2015"]},{"title":{"ja":"本学悪性中皮腫患者で検出される生殖細胞系列変異の疾患への寄与の検証","en":"Genetic variants associated with increased risk of malignant mesothelioma in Japanese."},"agency":{"ja":"Grant-in-Aid for Researchers from Hyogo College of Medicine","en":"Grant-in-Aid for Researchers from Hyogo College of Medicine"},"grantIds":["2017"]}],"relatedPublications":[{"title":"High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma","doi":"https://doi.org/10.1073/pnas.1612074113","datasets":["JGAD000116"]},{"title":"A Subset of Mesotheliomas With Improved Survival Occurring in Carriers of BAP1 and Other Germline Mutations","doi":"https://doi.org/10.1200/JCO.2018.79.0352","datasets":["JGAD000116"]}],"datasets":["JGAD000116"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"白石 航也","en":"Kouya Shiraishi"},"affiliation":{"ja":"ゲノム生物学研究分野, 国立研究開発法人国立がん研究センター研究所","en":"Division of Genome Biology, National Cancer Research Institute"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"ゲノム解析に基づく宿主並びに腫瘍における免疫応答ネットワーク機構の解明","en":"Elucidation of immune-system networks between host and tumor based on genomic analysis"},"periodStart":"2019-08-05","periodEnd":"2029-03-31","datasets":["JGAD000116"]},{"principalInvestigator":{"ja":"有田 正規","en":"Masanori Arita"},"affiliation":{"ja":"生命情報・DDBJ センター, 国立遺伝学研究所","en":"Bioinformation and DDBJ Center, National Institute of Genetics"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"DDBJ センターと NBDC による JGA 解析データの提供","en":"Provision of processed JGA data analyzed by DDBJ Center and NBDC"},"periodStart":"2021-10-07","periodEnd":"2030-03-31","datasets":["JGAD000116"]}]}