{"id":"hum0083","version":1,"url":"https://humandbs.dbcls.jp/research/hum0083/v1","datePublished":"2016-10-28","versions":[{"version":1,"datePublished":"2016-10-28"},{"version":2,"datePublished":"2022-01-24"}],"title":{"ja":"バイオマーカー探索に資する網羅的遺伝子解析研究（肺がん）","en":"Genome-wide analysis for biomarker exploration (lung cancer)"},"summary":{"aims":{"ja":"扁平上皮がん・非扁平上皮がんを鑑別するバイオマーカーの探索","en":"exploration of biomarkers discriminating squamous cell carcinoma from other lung cancers"},"methods":{"ja":"CAGE（Cap Analysis of Gene Expression）","en":"CAGE (Cap Analysis of Gene Expression)"},"targets":{"ja":"97＋38症例の肺がん（扁平上皮がんおよび非扁平上皮がん）および10症例の胸膜中皮腫摘出組織","en":"97 + 48 surgically dissected tissues"},"url":{"ja":null,"en":null}},"listingSummary":{},"releaseNote":{"ja":"97症例の肺がん（扁平上皮がんおよび非扁平上皮がん）摘出組織より抽出したRNAを使用してCAGEライブラリを作成し、Illumina HiSeq 2500によるシークエンシングを行った結果をfastqファイルにて提供する。","en":"RNA extracted from surgically dissected tissues from 97 patients with lung cancer were used for the preparation of CAGE libraries. Deep sequencing analysis on the libraries was performed with the Illumina HiSeq 2500 sequencer (47 bp, single-end) and provided in fastq and bam format files (reference: hg19)."},"dataProviders":[{"name":{"ja":"林崎 良英","en":"Yoshihide Hayashizaki"},"organization":{"name":{"ja":"理化学研究所 予防医療・診断技術開発プログラム","en":"RIKEN Preventive Medicine and Diagnosis Innovation Program"}}},{"name":{"ja":"向後 泰司","en":"Yasushi Kogo"},"organization":{"name":{"ja":"理化学研究所 科技ハブ産連本部","en":"RIKEN Cluster for Science, Technology and Innovation Hub"}}}],"researchProjects":[{"name":{"ja":"CAGE法による胸部悪性腫瘍における新規バイオマーカーの網羅的解析（順天堂大学 高持一矢）","en":"Genome-wide exploration for biomarkers in thoracic malignant tumors by using CAGE (Kazuya Takamochi, Juntendo University)"},"url":{"ja":null,"en":null}}],"grants":[{"title":{"ja":"CAGE法によるRNA解析を用いた肺原発扁平上皮癌に特異的なマーカーの開発","en":"Exploration of biomarkers specific to lung squamous cell carcinoma by using CAGE"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["25462185"]},{"title":{"ja":"胸部悪性腫瘍に対する個別化治療のためのバイオマーカーの探索とデータベースの構築","en":"Biomarker exploration and database development for personalized medicine against lung tumor"},"agency":{"ja":"公益財団法人 喫煙科学財団","en":"Smoking Research Foundation"},"grantIds":null},{"title":{"ja":null,"en":null},"agency":{"ja":"理化学研究所 オミックス基盤研究領域 運営費交付金","en":"Research Grant for RIKEN Omics Science Center from MEXT"},"grantIds":null},{"title":{"ja":null,"en":null},"agency":{"ja":"理化学研究所 予防医療・診断技術開発プログラム 運営費交付金","en":"Research Grant to RIKEN Preventive Medicine and Diagnosis Innovation Program from MEXT"},"grantIds":null},{"title":{"ja":"創薬等支援技術基盤プラットフォーム事業","en":"Platform for Drug Discovery, Informatics, and Structural Life Science"},"agency":{"ja":"日本医療研究開発機構（AMED） 創薬等ライフサイエンス研究支援基盤事業 創薬等先端技術支援基盤プラットフォーム（BINDS）","en":"Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS), Japan Agency for Medical Research and Development (AMED)"},"grantIds":null}],"relatedPublications":[{"title":"Novel biomarkers that assist in accurate discrimination of squamous cell carcinoma from adenocarcinoma of the lung","doi":"https://doi.org/10.1186/s12885-016-2792-1","datasets":["JGAD000070","JGAD000605"]}],"datasets":["JGAD000070"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"堀江 真史","en":"Masafumi Horie"},"affiliation":{"ja":"保健健康推進本部, 東京大学","en":"​Division for Health Service Promotion, The University of Tokyo"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"CAGE法を活用した非小細胞肺癌の新規バイオマーカーの探求","en":"Exploration of novel biomarkers of NSCLC using  CAGE seq."},"periodStart":"2017-01-11","periodEnd":"2017-08-18","datasets":["JGAD000070"]}]}