{"id":"hum0076","version":1,"url":"https://humandbs.dbcls.jp/research/hum0076/v1","datePublished":"2016-10-05","versions":[{"version":1,"datePublished":"2016-10-05"}],"title":{"ja":"日本人原発性胆汁性肝硬変の発症・進展に関わる遺伝因子の網羅的遺伝子解析","en":"Genome-wide search for susceptibility genes to primary biliary chirrosis"},"summary":{"aims":{"ja":"日本人原発性胆汁性肝硬変（Primary Biliary Cholangitis：PBC）の発症に関わる遺伝因子の網羅的遺伝子解析","en":"Genome-wide search for susceptibility genes to primary biliary cholangitis (PBC)"},"methods":{"ja":"Affymetrix Axiom ASI 1 Arrayを使用して約60万個の一塩基多型（Single Nucleotide Polymorphisms：SNPs）の遺伝子型を決定後ゲノムワイド関連解析（Genome-Wide Association Study：GWAS）を実施","en":"SNP-based genome-wide association study"},"targets":{"ja":"PBC 487 症例、および、健常対照者 476名","en":"487 PBCs and 476 healthy controls"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"ゲノムワイド関連","en":"Genome-wide association"},"targets":{"ja":"PBC：487症例\n対照：476名\n（日本人）","en":"487 PBCs\n476 controls\n(Japanese)"},"typeOfData":{"ja":"SNP-chip","en":"SNP-chip"}},"releaseNote":{"ja":"PBC 487症例、および、健常対照者 476名について、Affymetrix Axiom ASI 1 Arrayを使用して約60万個の一塩基多型（Single Nucleotide Polymorphisms：SNPs）の遺伝子型を決定後、ゲノムワイド関連解析（Genome-Wide Association Study：GWAS）を実施した結果を提供する（csv file）。","en":"A genome-wide association study for PBC was performed using SNPs on Affymetrix Axiom ASI 1 Array (420,928 SNPs)."},"dataProviders":[{"name":{"ja":"中村 稔","en":"Minoru Nakamura"},"organization":{"name":{"ja":"国立病院機構（NHO） 長崎医療センター 臨床研究センター","en":"Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center"}}}],"researchProjects":[{"name":{"ja":"PBC Consortium in Japan（PBCCJP）","en":"PBC Consortium in Japan (PBCCJP)"},"url":{"ja":null,"en":null}}],"grants":[{"title":{"ja":"原発性胆汁性肝硬変の新しい病型分類と長期予後診断法の確立","en":"New clinical classification and the criteria for predicting long-term outcome in primary biliary cirrhosis"},"agency":{"ja":"科学研究費助成事業 基盤研究(C)","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["20590800"]},{"title":{"ja":"日本人原発性胆汁性肝硬変の病態形成に関わる遺伝因子同定のための網羅的遺伝子解析","en":"Genome-wide association study to detect disease-associated genes in Japanese patients with primary biliary cirrhosis"},"agency":{"ja":"科学研究費助成事業 基盤研究(C)","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["23591006"]}],"relatedPublications":[{"title":"Genome-wide Association Study Identifies TNFSF15 and POU2AF1 as Susceptibility Loci for Primary Biliary Cirrhosis in the Japanese Population","doi":"https://doi.org/10.1016/j.ajhg.2012.08.010","datasets":["NHA000050"]}],"datasets":["NHA000050"],"controlledAccessUsers":[]}