{"id":"hum0075","secondaryIds":[],"version":2,"url":"https://humandbs.dbcls.jp/research/hum0075/v2","datePublished":"2019-02-19","versions":[{"version":1,"datePublished":"2017-09-25"},{"version":2,"datePublished":"2019-02-19"},{"version":3,"datePublished":"2022-05-27"}],"title":{"ja":"B型肝炎ウイルス感染の病態別における宿主遺伝因子の探索研究","en":"Search for susceptibility genes to hepatitis virus B-related diseases"},"summary":{"aims":{"ja":"B型肝炎ウイルス感染の病態別における宿主遺伝因子の探索","en":"Search for susceptibility genes to hepatitis virus B (HBV)-related diseases"},"methods":{"ja":"対象1〜3について、Affymetrix Genome-Wide Human SNP Array 6.0を使用して約90万個の一塩基多型（Single Nucleotide Polymorphisms：SNPs）の遺伝子型を決定後ゲノムワイド関連解析（Genome-Wide Association Study：GWAS）を実施\n対象4について、Affymetrix Axiom Genome-Wide ASI 1 Arrayを使用して約60万個のSNPsの遺伝子型を決定後GWASを実施","en":"SNP-based genome-wide association study (GWAS)"},"targets":{"ja":"1． B型肝炎ウイルスキャリア 181症例、および、健常対照者 184名\n2． B型肝炎ウイルスキャリア 181症例、および、B型肝炎ウイルス排除群 185症例\n3. B型肝炎ウイルス排除群 185症例、および、健常対照者 184名\n4. B型肝炎ウイルス陽性肝がん 473症例、および、B型肝炎ウイルスキャリア群（慢性肝炎および無症候キャリア） 516症例","en":"1. 181 HBV carriers and 184 controls\n2. 181 HBV carriers and 185 spontaneously HBV-resolved individuals\n3. 185 spontaneously HBV-resolved individuals and 184 controls\n4. 473 HBV-positive hepatocellular carcinoma (HCC) patients and 516 HBV carriers including chronic hepatitis and asymptomatic carriers"},"url":{"ja":null,"en":null}},"listingSummary":{},"releaseNote":{"ja":"B型肝炎ウイルス陽性肝がん473症例、および、B型肝炎ウイルスキャリア群（慢性肝炎および無症候キャリア）516症例について、Affymetrix Axiom Genome-Wide ASI 1 Arrayを使用して約60万SNPsの遺伝子型を決定後、GWAS結果を提供する（xlsx file）。","en":"A genome-wide association study for 473 HBV-positive HCC patients and 516 HBV carriers including chronic hepatitis and asymptomatic carriers was performed using SNPs on Affymetrix Axiom Genome-Wide ASI 1 Array (xlsx file)."},"dataProviders":[{"name":{"ja":"溝上 雅史","en":"Masashi Mizokami"},"organization":{"name":{"ja":"国立国際医療研究センター 肝炎免疫研究センター 肝疾患研究部","en":"Department of Liver Diseases, The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine"}}}],"researchProjects":[{"name":{"ja":"ゲノム医科学プロジェクト","en":"Genome Medical Science Project"},"url":{"ja":[{"url":"https://kohnodai.jihs.go.jp/kanen_meneki/index.html","text":"https://kohnodai.jihs.go.jp/kanen_meneki/index.html"}],"en":null}}],"grants":[{"title":{"ja":"ウイルス性肝炎に対する応答性を規定する宿主因子も含めた情報のデータベース構築・治療応用に関する研究","en":"Database construction and therapeutic applications including host genetic factors related with viral hepatitis"},"agency":{"ja":"厚生労働科学研究費補助金","en":"Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan"},"grantIds":["H22-kanen-005"]},{"title":{"ja":"B型肝炎ウイルス感染の病態別における宿主因子等について、網羅的な遺伝子解析を用い、新規診断法及び治療法の開発を行う研究","en":"Development of diagnostics and treatment for hepatitis B related diseases based on genome-wide genetic analysis"},"agency":{"ja":"厚生労働科学研究費補助金","en":"Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan"},"grantIds":["H23-kanen-005"]},{"title":{"ja":"ゲノム網羅的解析によるB型肝炎ウイルス感染の病態関連遺伝子の同定と新規診断法の開発","en":"Identification of genes associated with hepatitis B virus-related diseases by genome-wide analyses"},"agency":{"ja":"厚生労働科学研究費補助金","en":"Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan"},"grantIds":["H26-kanen-004"]},{"title":{"ja":"B型肝炎の慢性化・ウイルス排除に関連する遺伝要因について、HLAアリルおよび免疫関連遺伝子群を網羅的に探索する研究","en":"Identification of HLA allelss and immume-related genes associated with chronic hepatitis B and viral clearance"},"agency":{"ja":"厚生労働科学研究費補助金","en":"Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan"},"grantIds":["H25-kanen-012"]},{"title":{"ja":"B型肝炎の慢性化に関連する遺伝要因の探索","en":"Identification of host genetic factors related with chronic hepatitis B"},"agency":{"ja":"科学研究費助成事業 若手研究（B）","en":"KAKENHI Grant-in-Aid for Young Scientists (B)"},"grantIds":["25870178"]},{"title":{"ja":"B型肝炎の慢性化および癌化に関連する遺伝要因の網羅的探索","en":"Identification of host genetic factors related with chronic hepatitis B and HBV-related cancer"},"agency":{"ja":"宮川庚子記念研究財団平成26年度研究助成","en":"Miyakawa Memorial Research Foundation"},"grantIds":null}],"relatedPublications":[{"title":"Genome-Wide Association Study Confirming Association of HLA-DP with Protection against Chronic Hepatitis B and Viral Clearance in Japanese and Korean","doi":"https://doi.org/10.1371/journal.pone.0039175","datasets":["NHA000055","NHA000056","NHA000054"]},{"title":"Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma","doi":"https://doi.org/10.1038/s41598-018-26217-7","datasets":["NHA000079"]}],"datasets":["NHA000055","NHA000056","NHA000054","NHA000079"],"controlledAccessUsers":[]}