{"id":"hum0075","secondaryIds":[],"version":1,"url":"https://humandbs.dbcls.jp/research/hum0075/v1","datePublished":"2017-09-25","versions":[{"version":1,"datePublished":"2017-09-25"},{"version":2,"datePublished":"2019-02-19"},{"version":3,"datePublished":"2022-05-27"}],"title":{"ja":"B型肝炎ウイルス感染の病態別における宿主遺伝因子の探索研究","en":"Search for susceptibility genes to hepatitis virus B-related diseases"},"summary":{"aims":{"ja":"B型肝炎ウイルス感染の病態別における宿主遺伝因子の探索","en":"Search for susceptibility genes to hepatitis virus B (HBV)-related diseases"},"methods":{"ja":"Affymetrix Genome-Wide Human SNP Array 6.0を使用して約90万個の一塩基多型（Single Nucleotide Polymorphisms：SNPs）の遺伝子型を決定後ゲノムワイド関連解析（Genome-Wide Association Study：GWAS）を実施","en":"SNP-based genome-wide association study"},"targets":{"ja":"1． B型肝炎ウイルスキャリア 181症例、および、健常対照者 184名\n2． B型肝炎ウイルスキャリア 181症例、および、B型肝炎ウイルス排除群 185症例\n3. B型肝炎ウイルス排除群 185症例、および、健常対照者 184名","en":"1. 181 HBV carriers and 184 controls\n2. 181 HBV carriers and 185 spontaneously HBV-resolved individuals\n3. 185 spontaneously HBV-resolved individuals and 184 controls"},"url":{"ja":null,"en":null}},"listingSummary":{},"releaseNote":{"ja":"以下の対象について、Affymetrix Genome-Wide Human SNP Array 6.0を使用して約90万個の一塩基多型（Single Nucleotide Polymorphisms：SNPs）の遺伝子型を決定後ゲノムワイド関連解析（Genome-Wide Association Study：GWAS）を実施した結果を提供する（csv file）。\n1. B型肝炎ウイルスキャリア 181症例、健常対照者 184名（hum0075.v1.gwas.v1）\n2. B型肝炎ウイルスキャリア 181症例、B型肝炎ウイルス排除群 185症例（hum0075.v1.virus.v1）\n3. B型肝炎ウイルス排除群 185症例、健常対照者 184名（hum0075.v1.clear.v1）","en":"Genome-wide association studies for each group were performed using SNPs on Affymetrix Genome-Wide Human SNP Array 6.0.\n(1) 181 HBV carriers and 184 controls (hum0075.v1.gwas.v1)\n(2) 181 HBV carriers and 185 spontaneously HBV-resolved individuals (hum0075.v1.virus.v1)\n(3) 185 spontaneously HBV-resolved individuals and 184 controls (hum0075.v1.clear.v1)"},"dataProviders":[{"name":{"ja":"溝上 雅史","en":"Masashi Mizokami"},"organization":{"name":{"ja":"国立国際医療研究センター 肝炎免疫研究センター","en":"The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine"}}}],"researchProjects":[{"name":{"ja":"肝疾患研究部","en":"Department of Liver Diseases"},"url":{"ja":[{"url":"http://www.ncgmkohnodai.go.jp/kanen_meneki/index.html","text":"http://www.ncgmkohnodai.go.jp/kanen_meneki/index.html"}],"en":null}}],"grants":[{"title":{"ja":"ウイルス性肝炎に対する応答性を規定する宿主因子も含めた情報のデータベース構築・治療応用に関する研究","en":"Database construction and therapeutic applications including host genetic factors related with viral hepatitis"},"agency":{"ja":"厚生労働科学研究費補助金","en":"Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan"},"grantIds":["H22-kanen-005"]},{"title":{"ja":"B型肝炎ウイルス感染の病態別における宿主因子等について、網羅的な遺伝子解析を用い、新規診断法及び治療法の開発を行う研究","en":"Development of diagnostics and treatment for hepatitis B related diseases based on genome-wide genetic analysis"},"agency":{"ja":"厚生労働科学研究費補助金","en":"Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan"},"grantIds":["H23-kanen-005"]}],"relatedPublications":[{"title":"Genome-Wide Association Study Confirming Association of HLA-DP with Protection against Chronic Hepatitis B and Viral Clearance in Japanese and Korean","doi":"https://doi.org/10.1371/journal.pone.0039175","datasets":["NHA000055","NHA000056","NHA000054"]}],"datasets":["NHA000055","NHA000056","NHA000054"],"controlledAccessUsers":[]}