{"id":"hum0074","secondaryIds":[],"version":1,"url":"https://humandbs.dbcls.jp/research/hum0074/v1","datePublished":"2018-02-27","versions":[{"version":1,"datePublished":"2018-02-27"},{"version":2,"datePublished":"2018-09-25"}],"title":{"ja":"テーラーメイド治療を目指した肝炎ウイルスデータベース構築に関する研究","en":"Genome-wide association studies on Hepatitis C virus-related diseases and construction of genome database"},"summary":{"aims":{"ja":"テーラーメイド医療を目指した肝炎ウイルスデータベース構築","en":"Genome-wide association studies on Hepatitis C virus-related diseases and construction of genome database"},"methods":{"ja":"Affymetrix Genome-Wide Human SNP Array 6.0を使用して約90万個の一塩基多型（Single Nucleotide Polymorphisms：SNPs）の遺伝子型を決定後ゲノムワイド関連解析（Genome-Wide Association Study：GWAS）を実施","en":"SNP-based genome-wide association studies"},"targets":{"ja":"1. PEG-IFN/RBVの治療応答性（血中C型肝炎ウイルス排除の有無）\nC型肝炎ウイルスRNAの陰性化が得られない群（null virological response［NVR］）：78症例\nC型肝炎ウイルスRNAの持続陰性を示す群（sustained virological response［SVR］）：51症例\nC型肝炎ウイルス応答群（virological response［VR］）一時的にでも陰性化した群（SVR + transient virologic response［TVR］群）：64症例\n2. C型肝炎PEG-IFN/RBV併用療法による血小板減少\n血小板減少＋：107症例\n血小板減少-：196症例\n3. 進展に伴うヘモグロビン減少\nヘモグロビン減少＋：94症例\nヘモグロビン減少-：209症例","en":"1. virologic response to PEG-INF/RBV treatment\n78 null virologic response (NVR)\n64 virologic response (VR)\n51 sustained virologic response (SVR)\n2. decrease of PLT in response to PEG-IFN/RBV treatment\n107 HCV patients with decrease of PLT in response to PEG-IFN/RBV treatment\n196 HCV patients without decrease of PLT in response to PEG-IFN/RBV treatment\n3. Hb reduction\n94 HCV patients with Hb reduction\n209 HCV patients without Hb reduction"},"url":{"ja":null,"en":null}},"listingSummary":{},"releaseNote":{"ja":"以下の対象について、Affymetrix Genome-Wide Human SNP Array 6.0を使用して遺伝子型決定を行い、ゲノムワイド関連解析（Genome-Wide Association Study：GWAS）を実施した結果を提供する（cvs file）。\n1. C型肝炎ウイルス著効（血中C型肝炎ウイルス排除の有無）\nC型肝炎ウイルスRNAの陰性化が得られない群（null virological response［NVR］）：78症例\nC型肝炎ウイルスRNAの持続陰性を示す群（sustained virological response［SVR］）：51症例\nC型肝炎ウイルス応答群（virological response［VR］：SVR + transient virologic response［TVR］群）：64症例\n2. C型肝炎PEG-IFN/RBV併用療法による血小板減少\n血小板減少有：107症例\n血小板減少無：196症例\n3. 進展に伴うヘモグロビン減少\nヘモグロビン減少有：94症例\nヘモグロビン減少無：209症例","en":"A genome-wide association studies for following symptoms were performed by using of Affymetrix Genome-Wide Human SNP Array 6.0.\n(1) 78 null virologic response, 64 virologic response, and 51 sustained virologic response (43 SNPs)\n(2) 107 HCV patients with decrease of PLT in response to PEG-IFN/RBV treatment and 196 HCV patients without decrease of PLT in response to PEG-IFN/RBV treatment (66 SNPs)\n(3) 94 HCV patients with Hb reduction and 209 HCV patients without Hb reduction (32 SNPs)"},"dataProviders":[{"name":{"ja":"田中 靖人","en":"Yasuhito Tanaka"},"organization":{"name":{"ja":"名古屋市立大学大学院 医学研究科 ウイルス学","en":"Department of Virology, Graduate School of Medical Sciences, Nagoya City University"}}}],"researchProjects":[],"grants":[{"title":{"ja":"テーラーメイド治療を目指した肝炎ウイルスデーターベース構築に関する研究","en":"Construction of hepatitis virus related database aiming at personalized medicine"},"agency":{"ja":"厚生労働科学研究費補助金","en":"Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan"},"grantIds":["H19-kanen-013"]},{"title":{"ja":"ウイルス性肝炎に対する応答性を規定する宿主因子も含めた情報のデータベース構築・治療応用に関する研究","en":"Database construction and therapeuitic applications including host genetic factors for hepatitis virus related diseases"},"agency":{"ja":"厚生労働科学研究費補助金","en":"Grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan"},"grantIds":["H22-kanen-005"]}],"relatedPublications":[{"title":"Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C","doi":"https://doi.org/10.1038/ng.449","datasets":["NHA000064"]},{"title":"Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C","doi":"https://doi.org/10.1093/hmg/ddr249","datasets":["NHA000063","NHA000062"]}],"datasets":["NHA000064","NHA000063","NHA000062"],"controlledAccessUsers":[]}