{"id":"hum0067","version":1,"url":"https://humandbs.dbcls.jp/research/hum0067/v1","datePublished":"2017-05-18","versions":[{"version":1,"datePublished":"2017-05-18"}],"title":{"ja":"卵巣明細胞腺癌に対する新規バイオマーカーの検索と化学療法感受性に関する後方視的検討","en":"Project for Development of Innovative Research on Cancer Therapeutics; identifiying the predictive factors for response to chemoherapy in ovarian cancer"},"summary":{"aims":{"ja":"卵巣明細胞腺がんに対する新規バイオマーカーの検索と化学療法感受性に関する検討","en":"To identify novel predictive biomarkers of response to chemotherapy for clear cell carcinoma of the ovary"},"methods":{"ja":"Illumina HiSeq 2000を使用したExome解析","en":"whole exome sequencing by using of Illumina HiSeq 2000"},"targets":{"ja":"卵巣明細胞腺がん55症例の腫瘍組織と非腫瘍組織（末梢血または間質組織）の合計110検体","en":"110 samples (non-tumor and tumor tissues) from 55 ovarian clear cell carcinoma patients"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"卵巣明細胞腺癌：55症例\n（日本人）","en":"55 ovarian clear cell carcinoma patients\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome）","en":"NGS\n(Exome)"}},"releaseNote":{"ja":"このバージョンでは、卵巣明細胞腺がん55症例の腫瘍組織もしくは非腫瘍組織（末梢血または間質組織）から抽出したDNAを使用したExome解析の結果をFastqファイルにて提供する。HiSeq 2000（Illumina）を用いて平均長150から200塩基のDNA断片を解読した（Paired-end）。","en":"DNAs extracted from110 non-tumor or tumor tissues (55 ovarian clear cell carcinoma patients) were used for the whole exome sequencing (fastq files).\nExons were narrowed down by using of SureSelect Human All Exon V5 + lincRNA and read by Illumina HiSeq 2000 (paired-end: 100 bp x 2)."},"dataProviders":[{"name":{"ja":"杉山 徹","en":"Toru Sugiyama"},"organization":{"name":{"ja":"岩手医科大学 医学部 産婦人科学講座","en":"Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine"}}}],"researchProjects":[],"grants":[{"title":{"ja":"卵巣がんにおける化学療法効果規定因子の探索","en":"Identifiying the predictive factors for response to chemoherapy in ovarian cancer"},"agency":{"ja":"文部科学省 次世代がん研究シーズ戦略的育成プログラム","en":"Project for Development of Innovative Research on Cancer Therapeutics"},"grantIds":null}],"relatedPublications":[],"datasets":["JGAD000076"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"万代 昌紀","en":"Masaki Mandai"},"affiliation":{"ja":"婦人科学産科学教室, 京都大学医学部医学研究科","en":"department of Gynecology and Obstetrics, Kyoto University Faculty of Medicene"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"多様な臨床情報を考慮した婦人科悪性腫瘍患者のオミックス解析（全ゲノム・全トランスクリプトーム・プロテオーム・メタボローム解析）による個別化治療の探索","en":"Integrated analyses of omics (genomics, transcriptomics, proteomics and metabolomics) associated with clinical variables for developing indivisualizedtreatment in gynecological malignancy"},"periodStart":"2018-10-04","periodEnd":"2025-04-14","datasets":["JGAD000076"]},{"principalInvestigator":{"ja":"白石 航也","en":"Kouya Shiraishi"},"affiliation":{"ja":"ゲノム生物学研究分野, 国立研究開発法人国立がん研究センター研究所","en":"Division of Genome Biology, National Cancer Research Institute"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"ゲノム解析に基づく宿主並びに腫瘍における免疫応答ネットワーク機構の解明","en":"Elucidation of immune-system networks between host and tumor based on genomic analysis"},"periodStart":"2019-08-05","periodEnd":"2029-03-31","datasets":["JGAD000076"]},{"principalInvestigator":{"ja":"角田 達彦","en":"Tatsuhiko Tsunoda"},"affiliation":{"ja":"大学院生物科学専攻医科学数理研究室, 東京大学","en":"Tsunoda Laboratory (Medical Science Mathematics), Department of Biological Sciences, Graduate School of Science, The University of Tokyo"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"オーダーメイド医療のためのシーケンス、画像データなどの解析に関する研究（9）","en":"Research on sequence, image data analysis for precision medicine (9)"},"periodStart":"2021-07-09","periodEnd":"2025-07-07","datasets":["JGAD000076"]},{"principalInvestigator":{"ja":"松村 謙臣","en":"Noriomi Matsumura"},"affiliation":{"ja":"産科婦人科学教室, 近畿大学医学部","en":"Obstetrics and Gynecology, Kindai University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"JGOG3017-TR1：エクソームシークエンスデータを有する卵巣明細胞癌のRNAseq解析","en":"Integrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR1"},"periodStart":"2024-10-15","periodEnd":"2027-12-31","datasets":["JGAD000076"]},{"principalInvestigator":{"ja":"山口 建","en":"Ken Yamaguchi"},"affiliation":{"ja":"婦人科学産婦人科学教室, 京都大学","en":"Gynecology and Obstetrics, Kyoto University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"JGOG3017-TR1：エクソームシークエンスデータを有する卵巣明細胞癌のRNAseq解析","en":"Integrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR1"},"periodStart":"2024-10-22","periodEnd":"2027-12-31","datasets":["JGAD000076"]}]}