{"id":"hum0066","version":1,"url":"https://humandbs.dbcls.jp/research/hum0066/v1","datePublished":"2016-08-01","versions":[{"version":1,"datePublished":"2016-08-01"}],"title":{"ja":"癌の再発・転移に関与するnon-coding RNAの同定とその機序の解明","en":"Investigating the mechanisms of tumor recurrence and metastasis by non-coding RNA"},"summary":{"aims":{"ja":"大腸がんのゲノムレベルの腫瘍内不均一性について明らかにする","en":"Investigating a genomic-level intratumor heterogeneity in colorectal carcinoma"},"methods":{"ja":"大腸がんと肝転移巣の腫瘍組織および非腫瘍組織より抽出したDNAを使用したエクソーム解析","en":"DNA were extracted from multiregional tumor samples and performed a whole exome sequencing analysis"},"targets":{"ja":"根治的腫瘍切除術を実施した大腸がん9症例","en":"Samples which obtained during surgery from patients who underwent radical resection of primary and/or liver metastatic tumors"},"url":{"ja":[{"url":"https://www.kyushu-u.ac.jp/f/5858/2016_02_19_2.pdf","text":"https://www.kyushu-u.ac.jp/f/5858/2016_02_19_2.pdf"}],"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"大腸癌：9症例\n（日本人）","en":"9 colorectal carcinomas\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome）","en":"NGS\n(Exome)"}},"releaseNote":{"ja":"根治的腫瘍切除術を実施した大腸がん9症例の腫瘍組織、肝転移巣、および非腫瘍組織（正常組織）から抽出したDNAを使用したExome解析の結果をFastqファイルにて提供する。\nAgilent社のSureSelect Human All Exon V4またはV5を使用してExon領域にしぼり、HiSeq 2000にて平均長227塩基のDNA断片を解読した（Paired-end）。","en":"DNAs extracted from tumors, non-cancerous tissues or liver metastatic tumors from 9 colorectal carcinomas were used for the whole exome sequencing (Fastq files).\nExons were narrowed down by using of SureSelect Human All Exon v4/v5 and read by Illumina HiSeq 2000 (paired-end: 100 bp)."},"dataProviders":[{"name":{"ja":"三森 功士","en":"Koshi Mimori"},"organization":{"name":{"ja":"九州大学病院 別府病院 外科","en":"Department of Surgery, Kyushu University Beppu Hospital"}}}],"researchProjects":[],"grants":[{"title":{"ja":"癌の再発・転移に関与する non-coding RNA の同定とその機序解明","en":"Investigating mechanism of tumor recurrence and metastasis by non-coding RNA"},"agency":{"ja":"先端研究助成基金助成金（最先端・次世代研究開発支援プログラム）","en":"Funding Program for Next Generation World-Leading Researchers (NEXT Program)"},"grantIds":["LS094"]},{"title":{"ja":"システム的統合理解に基づくがんの先端的診断、治療、予防法の開発","en":"Systems Cancer Research"},"agency":{"ja":"科学研究費助成事業 新学術領域研究","en":"KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas"},"grantIds":["4201"]},{"title":{"ja":"大腸癌におけるMYCとの合成致死作用を持つ遺伝子の同定","en":"Supercomputational Life Science"},"agency":{"ja":"科学研究費助成事業 若手研究(B)","en":"Strategic Programs for Innovative Research (SPIRE) Field 1"},"grantIds":["25861199"]},{"title":{"ja":"予測する生命科学・医療および創薬基盤","en":"Supercomputational Life Science"},"agency":{"ja":"HPCI戦略プログラム 分野1","en":"HPCI Strategic Programs for Innovative Research (SPIRE) Field 1"},"grantIds":["SCLS課題4"]}],"relatedPublications":[{"title":"Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution.","doi":"https://doi.org/10.1371/journal.pgen.1005778","datasets":["JGAD000060"]}],"datasets":["JGAD000060"],"controlledAccessUsers":[{"principalInvestigator":{"en":"Christina Curtis"},"affiliation":{"en":"Stanford University"},"country":{"ja":"アメリカ合衆国 (カリフォルニア州)","en":"California, United States"},"researchTitle":{"ja":"Analysis of multi-region sequencing data to delineate patterns of tumor heterogeneity","en":"Analysis of multi-region sequencing data to delineate patterns of tumor heterogeneity"},"periodStart":"2016-08-05","periodEnd":"2023-07-13","datasets":["JGAD000060"]},{"principalInvestigator":{"ja":"白石 航也","en":"Kouya Shiraishi"},"affiliation":{"ja":"ゲノム生物学研究分野, 国立研究開発法人国立がん研究センター研究所","en":"Division of Genome Biology, National Cancer Research Institute"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"ゲノム解析に基づく宿主並びに腫瘍における免疫応答ネットワーク機構の解明","en":"Elucidation of immune-system networks between host and tumor based on genomic analysis"},"periodStart":"2019-08-05","periodEnd":"2029-03-31","datasets":["JGAD000060"]},{"principalInvestigator":{"en":"Ruping Sun"},"affiliation":{"en":"Department of laboratory medicine and pathology, University of Minnesota"},"country":{"ja":"アメリカ合衆国 (ミネソタ州)","en":"Minnesota, United States"},"researchTitle":{"ja":"Accounting for Copy Number States in Quantifying Tumor Heterogeneity","en":"Accounting for Copy Number States in Quantifying Tumor Heterogeneity"},"periodStart":"2020-03-19","periodEnd":"2023-01-16","datasets":["JGAD000060"]}]}