{"id":"hum0064","version":1,"url":"https://humandbs.dbcls.jp/research/hum0064/v1","datePublished":"2016-08-26","versions":[{"version":1,"datePublished":"2016-08-26"}],"title":{"ja":"高齢者がん治療アルゴリズム開発のためのガイドポスト・データベースの構築と必須情報及びその推定モデル","en":"Construction of Geriatric Oncology Database for establishment of the Treatment Algorithm: Clinical Data and Questionnaire Survey Results in JapaneseElderly Cancer Patients Retrospective study"},"summary":{"aims":{"ja":"高齢者がん医療に関わる情報データベース（ガイドポスト・データベース）を構築し、高齢者がん症例における（1）各種治療法の有用性の検証（2）治療リスク予測指標・臓器予備能・治療応答の初期推定モデルの策定、を実施することで、高齢者のがん治療アルゴリズムを構築する。","en":"To construct a Geriatric Oncology Database of genotype, methylation, gene expression, clinical data, and questionnaire survey results in Japanese elderly cancer patients and attempt to establish truly effective treatment strategy"},"methods":{"ja":"【ゲノム・遺伝子解析研究】\n大腸がん、胃がん、肺がん症例の臨床データ、遺伝子多型・変異データ（ダイレクトシークエンス法、TaqMan法）、発現解析データ（qRT-PCR法）、メチル化解析データ（Combined Bisulfite Restriction Analysis：COBRA法）、大腸がんおよび胃がん症例の発現解析データ（マイクロアレイ法）\n【後ろ向き研究】\n大腸がん、胃がん、肺がん、糖尿病・腎障害、循環器疾患、呼吸器疾患症例の治療情報および臨床情報（検査値・高齢者特性）","en":"1. Genome & Genetic research\nDirect sequencing, TaqMan analysis, qRT-PCR, COBRA assay, cDNA microarray. Collection of clinical data and digitalization of them.\n2. Retrospective study\nCollection of clinical data and digitalization of them. Collection of questionnaires and digitalization of them."},"targets":{"ja":"【ゲノム・遺伝子解析研究】\n大腸がん：106症例、胃がん：62症例、肺がん：173症例\n【後ろ向き研究】\n大腸がん：313 症例、胃がん：166 症例、肺がん：344 症例、糖尿病・腎障害：300 症例、循環器疾患：357 症例、呼吸器疾患：49 症例","en":"1. Genome & Genetic research\ncolorectal cancer: 106 cases, gastric cancer: 62 cases, lung cancer: 173 cases\n2. Retrospective study\ncolorectal cancer: 313 cases, gastric cancer: 166 cases, lung cancer: 344 cases\ndiabetes and nephropathy: 300 cases, cardiovascular disorder: 357 cases, respiratory dysfunction: 49 cases"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定\n発現\nメチル化","en":"Sequencing, expression profiling, methylation profiling"},"targets":{"ja":"【ゲノム】\n大腸癌：106症例\n胃癌：62症例\n肺癌：173症例\n【後向き】\n大腸癌：313 症例\n胃癌：166 症例\n肺癌：344 症例\n糖尿・腎障害：300 症例\n循環器疾患：357 症例\n呼吸器疾患：49 症例\n（日本人）","en":"[GENOME]\n106 colorectal cancer\n62 gastric cancer\n173 lung cancer\n[Retrospective]\n313 colorectal cancer\n166 gastric cancer\n344 lung cancer\n300 diabetes and nephropathy\n357 cardiovascular disorder\n49 respiratory dysfunction\n(Japanese)"},"typeOfData":{"ja":"*サンガー\nTaqMan\nqRT-PCR\nマイクロアレイ\nCOBRA\n治療情報\n臨床情報","en":"Direct sequencing\nTaqMan\nqRT-PCR\nCOBRA\ncDNA microarray\nClinical data\nTreatment data"}},"releaseNote":{"ja":"以下の研究に関するデータの一覧および発現アレイの補正後の値をtxtファイルにて提供する。\n【ゲノム・遺伝子解析研究】\n大腸がん、胃がん、肺がん症例の治療情報、臨床情報、遺伝子型データ（ダイレクトシークエンス法、TaqMan法）、発現解析データ（qRT-PCR法）、メチル化解析データ（Combined Bisulfite Restriction Analysis：COBRA法）、大腸がん、および、胃がん症例の発現アレイの標準化値（マイクロアレイ法）\n【後ろ向き研究】\n大腸がん、胃がん、肺がん、糖尿病・腎障害、循環器疾患、呼吸器疾患症例の治療情報、および、臨床情報（検査値・高齢者特性）","en":"This study provides the following data in text files:\n1. Genome & Genetic research\nClinical data, genotype data (direct sequencing, TaqMan assay), gene expression data (qRT-PCR) and methylation data (COBRA assay) for colorectal, gastric, or lung cancer patients.\nNormalized values of cDNA microarray for colorectal or gastric cancer patients.\n2. Retrospective study\nCollection of clinical data about colorectal cancer, gastric cancer, lung cancer, diabetes, nephropathy, cardiovascular disorder, or respiratory dysfunction patients."},"dataProviders":[{"name":{"ja":"西山 正彦","en":"Masahiko Nishiyama"},"organization":{"name":{"ja":"群馬大学大学院 医学系研究科 病態腫瘍薬理学分野","en":"Department of Molecular Pharmacology and Oncology, Gunma University Graduate School of Medicine"}}}],"researchProjects":[{"name":{"ja":"厚生労働科学研究費補助金・第3次対がん総合戦略研究事業","en":"Third Term Comprehensive Control Research for Cancer Health and Labor Sciences Research Grants of the Ministry of Health, Labor and Welfare of Japan."},"url":{"ja":null,"en":null}}],"grants":[{"title":{"ja":"高齢者がん治療アルゴリズム開発のためのガイドポスト・データベースの構築と必須情報及びその推定モデルの策定","en":"Geriatric Oncology Database of genotypes and methylation, gene expression, clinical data, and survey results on psychosocial and physical conditions in Japanese elderly cancer patients to establish truly effective treatment strategy"},"agency":{"ja":"厚生労働科学研究費補助金・第3次対がん総合戦略研究経費","en":"Third Term Comprehensive Control Research for Cancer Health and Labor Sciences Research Grants of the Ministry of Health, Labor and Welfare of Japan."},"grantIds":["一般-010"]}],"relatedPublications":[{"title":"Impact of age on epidermal growth factor receptor mutation in lung cancer.","doi":"https://doi.org/10.1016/j.lungcan.2012.09.006","datasets":["JGAD000061"]},{"title":"Association between a genome-wide association study-identified locus and the risk of lung cancer in Japanese population.","doi":"https://doi.org/10.1097/JTO.0b013e3182475028","datasets":["JGAD000061"]},{"title":"Thoracic radiotherapy with or without daily low-dose carboplatin in elderly patients with non-small-cell lung cancer: a randomised, controlled, phase 3 trial by the Japan Clinical Oncology Group (JCOG0301)","doi":"https://doi.org/10.1016/S1470-2045(12)70139-0","datasets":["JGAD000061"]},{"title":"Progression-free survival as a surrogate for overall survival in advanced/recurrent gastric cancer trials: a meta-analysis.","doi":"https://doi.org/10.1093/jnci/djt269","datasets":["JGAD000061"]},{"title":"Risk factors associated with recurrence of surgically resected node-positive non-small cell lung cancer.","doi":"https://doi.org/10.1007/s00595-015-1301-5","datasets":["JGAD000061"]},{"title":"Genetic and Prognostic Differences of Non-small Cell Lung Cancer between Elderly Patients and Younger Counterparts.","doi":null,"datasets":["JGAD000061"]}],"datasets":["JGAD000061"],"controlledAccessUsers":[]}