{"id":"hum0059","version":1,"url":"https://humandbs.dbcls.jp/research/hum0059/v1","datePublished":"2018-04-06","versions":[{"version":1,"datePublished":"2018-04-06"}],"title":{"ja":"卵巣がんの再発に特徴的な遺伝子変異の同定","en":"Identification of genetic mutations characteristic for recurrence of serous ovarian cancer"},"summary":{"aims":{"ja":"漿液性卵巣がんにおいて分子プロファイリングをもとに難治がん克服のための新たな治療戦略を確立する。","en":"Establishment of novel therapeutic strategy to overcome intractable cancer by molecular profiling of serous ovarian cancer"},"methods":{"ja":"Illumina HiSeq 2000を使用したExome解析","en":"Exome analysis by using Illumina HiSeq 2000"},"targets":{"ja":"卵巣がん65症例の正常組織と原発巣・再発巣の腫瘍組織の合計148検体","en":"148 normal, primary tumor and relapse tumor tissues from 65 ovarian cancer"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"卵巣癌：65症例\n（日本人）","en":"65 ovarian cancer\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome）","en":"NGS\n(Exome)"}},"releaseNote":{"ja":"卵巣がん65症例の正常組織と原発巣、再発巣の腫瘍組織から抽出したDNAを用いたExome解析の結果をFastqファイルにて提供する。\nSureSelect Human All Exon V4 + lincRNA または SureSelect Human All Exon V5 + lincRNAを用いてExon領域にしぼりIllumina HiSeq 2000にて平均長100塩基のDNA断片を解読した（Paired-end）。","en":"DNAs extracted from normal, primary tumor and relapse tumor tissues from 65 ovarian cancer patients were used for the whole exome sequencing (fastq files).\nExons were narrowed down by using of SureSelect Human All Exon V4 + lincRNA or SureSelect Human All Exon V5 + lincRNA and read by Illumina Hiseq 2000 (paired-end: 100 bp)."},"dataProviders":[{"name":{"ja":"加藤 一喜","en":"Kazuyoshi Kato"},"organization":{"name":{"ja":"がん研有明病院","en":"The Cancer Institute Hospital of JFCR"}}}],"researchProjects":[],"grants":[{"title":{"ja":"分子プロファイリングによる新規標的同定を通じた難治がん治療法開発（進行性卵巣がんの治療感受性を規定する遺伝子変異の同定）","en":"Development of the Intractable Cancer Therapies through the New Target Identification by the Molecular Profiling"},"agency":{"ja":"日本医療研究開発機構（AMED） 次世代がん研究シーズ戦略的育成プログラム（P-DIRECT）","en":"Project for Development of Innovative Research on Cancer Therapeutics (P-DIRECT), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP15cm0106061"]},{"title":{"ja":"先進的がん治療法開発のためのマルチオミック解析による基盤的基礎研究（患者腫瘍検体のゲノム・エピゲノム情報解析とデータベース構築）"},"agency":{"ja":"科学研究費助成事業（科学研究費補助金）（特定奨励費）","en":"JSPS KAKENHI"},"grantIds":null}],"relatedPublications":[],"datasets":["JGAD000109"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"万代 昌紀","en":"Masaki Mandai"},"affiliation":{"ja":"婦人科学産科学教室, 京都大学医学部医学研究科","en":"department of Gynecology and Obstetrics, Kyoto University Faculty of Medicene"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"多様な臨床情報を考慮した婦人科悪性腫瘍患者のオミックス解析（全ゲノム・全トランスクリプトーム・プロテオーム・メタボローム解析）による個別化治療の探索","en":"Integrated analyses of omics (genomics, transcriptomics, proteomics and metabolomics) associated with clinical variables for developing indivisualizedtreatment in gynecological malignancy"},"periodStart":"2018-10-04","periodEnd":"2025-04-14","datasets":["JGAD000109"]},{"principalInvestigator":{"ja":"白石 航也","en":"Kouya Shiraishi"},"affiliation":{"ja":"ゲノム生物学研究分野, 国立研究開発法人国立がん研究センター研究所","en":"Division of Genome Biology, National Cancer Research Institute"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"ゲノム解析に基づく宿主並びに腫瘍における免疫応答ネットワーク機構の解明","en":"Elucidation of immune-system networks between host and tumor based on genomic analysis"},"periodStart":"2019-08-05","periodEnd":"2029-03-31","datasets":["JGAD000109"]},{"principalInvestigator":{"ja":"松村 謙臣","en":"Noriomi Matsumura"},"affiliation":{"ja":"産科婦人科学教室, 近畿大学医学部","en":"Obstetrics and Gynecology, Kindai University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"JGOG3017-TR1：エクソームシークエンスデータを有する卵巣明細胞癌のRNAseq解析","en":"Integrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR1"},"periodStart":"2024-10-15","periodEnd":"2027-12-31","datasets":["JGAD000109"]},{"principalInvestigator":{"ja":"山口 建","en":"Ken Yamaguchi"},"affiliation":{"ja":"婦人科学産婦人科学教室, 京都大学","en":"Gynecology and Obstetrics, Kyoto University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"JGOG3017-TR1：エクソームシークエンスデータを有する卵巣明細胞癌のRNAseq解析","en":"Integrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR1"},"periodStart":"2024-10-22","periodEnd":"2027-12-31","datasets":["JGAD000109"]}]}