{"id":"hum0030","secondaryIds":[],"version":1,"url":"https://humandbs.dbcls.jp/research/hum0030/v1","datePublished":"2015-04-21","versions":[{"version":1,"datePublished":"2015-04-21"},{"version":2,"datePublished":"2024-05-10"},{"version":3,"datePublished":"2024-07-05"},{"version":4,"datePublished":"2025-07-01"},{"version":5,"datePublished":"2026-04-22"},{"version":6,"datePublished":"2026-10-22"}],"title":{"ja":"婦人科臓器に発生する悪性腫瘍の発症に関連する分子生物学的異常の検索","en":"The Molecular Biological Analysis about Occurrence and Malignant Transformation in gynecological carcinogenesis"},"summary":{"aims":{"ja":"卵巣明細胞腺がんと他の卵巣がん組織型におけるゲノムコピー数の違いを比較することで、卵巣明細胞腺がんの分子生物学的特徴を明らかにする。","en":"To clarify the molecular biological difference between ovarian clear cell carcinoma and other histological subtypes carcinomas by comparing the copy number variants."},"methods":{"ja":"ゲノムワイドSNPタイピングアレイを使用し約26万個のSNPプローブの蛍光強度を測定し、がんと正常を比較することでコピー数異常を検出する。","en":"Gene Chip Human Mapping 250K Nsp Arrays were used for detecting the signal intensity of about 260 thousands SNPs and intensities of ovarian clear cell carcinoma were compared to the ones of non-carcinoma."},"targets":{"ja":"卵巣がん57症例（腫瘍組織・末梢血、計114検体）","en":"57 ovarian carcinoma patients (ovarian cancer cells and peripheral blood cells: total 114 samples)"},"url":{"ja":null,"en":null}},"listingSummary":{},"releaseNote":{"ja":"Affymetrix [GeneChip Human Mapping 250K Nsp Array]を使用した卵巣がん切片の腫瘍組織および末梢血における約26万SNPs情報をCELファイルにて提供する。","en":"Signal intensities for 260K CNVs of 57 ovarian carcinomas were decided by using of GeneChip Human Mapping 250K Nsp Arrays (Affymetrix) (CEL files)."},"dataProviders":[{"name":{"ja":"織田 克利","en":"Katsutoshi Oda"},"organization":{"name":{"ja":"東京大学医学部 産科婦人科学教室","en":"Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo"}}}],"researchProjects":[],"grants":[{"title":{"ja":"統合的ゲノム解析によるがん細胞集団進化の解明","en":"An Integrated Genomic Analysis on Evolution of Cancer Cell Population"},"agency":{"ja":"科学研究費助成事業 基盤研究（S）","en":"KAKENHI Grant-in-Aid for Scientific Research (S)"},"grantIds":["24221011"]},{"title":{"ja":"子宮体癌・卵巣癌においてアポトーシスを誘導する新規分子標的治療法の探","en":"Search for the New Molecular Targeted Therapies and Biomarkers Inducing Apoptosis in Endometrial Carcinoma and Ovarian Carcinoma"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["26462515"]},{"title":{"ja":"卵巣明細胞腺癌における遺伝子プロファイルに基づく新規分子標的治療法の探索","en":"Search for the New Molecular Targeted Therapies Based on Genetic Profiles of Ovarian Clear Cell Carcinoma"},"agency":{"ja":"科学研究費助成事業 若手研究（B）","en":"KAKENHI Grant-in-Aid for Young Scientists (B)"},"grantIds":["25861473"]},{"title":{"ja":"「分子プロファイリングによる新規標的同定を通じた難治がん治療法開発」 （進行性卵巣がんの治療感受性を規定する遺伝子変異の同定）","en":"Development of the Intractable Cancer Therapies through the New Target Identification by the Molecular Profiling (The Identification of the Gene Variation to Regulate the Treatment Sensitivity of the Progressive Ovarian Cancer)"},"agency":{"ja":"日本医療研究開発機構（AMED） 次世代がん研究シーズ戦略的育成プログラム（P-DIRECT）","en":"Project for Development of Innovative Research on Cancer Therapeutics (P-DIRECT), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["11114014"]}],"relatedPublications":[{"title":"Integrated Copy Number and Expression Analysis Identifies Profiles of Whole-Arm Chromosomal Alterations and Subgroups with Favorable Outcome in Ovarian Clear Cell Carcinomas","doi":"https://doi.org/10.1371/journal.pone.0128066","datasets":["JGAD000022","JGAD000682"]}],"datasets":["JGAD000022"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"小西 郁生","en":"Ikuo Konishi"},"affiliation":{"ja":"婦人科産科学, 京都大学大学院医学研究科器官外科学","en":"Department of Gynecology and Obstetrics, Kyoto University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"多様な臨床情報を考慮した婦人科悪性腫瘍患者のオミックス解析（全ゲノム・全トランスクリプトーム・プロテオーム・メタボローム解析）による個別化治療の探索","en":"Integrated analyses of omics (genomics, transcriptomics, proteomics and metabolomics) associated with clinical variables for developing indivisualized treatment in gynecologycal malignancy"},"periodStart":"2015-07-03","periodEnd":"2017-09-04","datasets":["JGAD000022"]},{"principalInvestigator":{"ja":"万代 昌紀","en":"Masaki Mandai"},"affiliation":{"ja":"婦人科学産科学教室, 京都大学医学部医学研究科","en":"department of Gynecology and Obstetrics, Kyoto University Faculty of Medicene"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"多様な臨床情報を考慮した婦人科悪性腫瘍患者のオミックス解析（全ゲノム・全トランスクリプトーム・プロテオーム・メタボローム解析）による個別化治療の探索","en":"Integrated analyses of omics (genomics, transcriptomics, proteomics and metabolomics) associated with clinical variables for developing indivisualizedtreatment in gynecological malignancy"},"periodStart":"2018-10-04","periodEnd":"2025-04-14","datasets":["JGAD000022"]},{"principalInvestigator":{"ja":"松村 謙臣","en":"Noriomi Matsumura"},"affiliation":{"ja":"産科婦人科学教室, 近畿大学医学部","en":"Obstetrics and Gynecology, Kindai University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"JGOG3017-TR1：エクソームシークエンスデータを有する卵巣明細胞癌のRNAseq解析","en":"Integrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR1"},"periodStart":"2024-10-15","periodEnd":"2027-12-31","datasets":["JGAD000022","JGAD000682","JGAD000931"]},{"principalInvestigator":{"ja":"山口 建","en":"Ken Yamaguchi"},"affiliation":{"ja":"婦人科学産婦人科学教室, 京都大学","en":"Gynecology and Obstetrics, Kyoto University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"JGOG3017-TR1：エクソームシークエンスデータを有する卵巣明細胞癌のRNAseq解析","en":"Integrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR1"},"periodStart":"2024-10-22","periodEnd":"2027-12-31","datasets":["JGAD000022","JGAD000682","JGAD000931"]}]}