{"id":"hum0023","version":1,"url":"https://humandbs.dbcls.jp/research/hum0023/v1","datePublished":"2015-01-28","versions":[{"version":1,"datePublished":"2015-01-28"}],"title":{"ja":"生活習慣病、動脈硬化性疾患、ならびに抗加齢に関する遺伝疫学研究","en":"Genetic Analysis in Lifestyle-Related Disease, Arteriosclerotic Disease, and Aging-Related Diseases"},"summary":{"aims":{"ja":"高血圧症の遺伝因子の解明","en":"Identify susceptible genes in hypertension"},"methods":{"ja":"Illumina HiSeq 2000を使用したExome解析","en":"Whole Exome sequencing by using of Illumina HiSeq 2000"},"targets":{"ja":"III度以上の本態性高血圧患者30症例","en":"Patients with severe hypertension"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"III度以上の本態性\n高血圧：30症例\n（日本人）","en":"30 Hypertensions\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome）","en":"NGS\n(Exome)"}},"releaseNote":{"ja":"このバージョンでは、III度以上の本態性高血圧患者30症例の末梢血から抽出したDNAを用いたExome解析の結果をFastqファイルにて提供する。SureSelect Human All Exon 50 Mb Kit（Agilent社）を用いてExon領域にしぼり、Illumina 社 HiSeq 2000にて平均長100塩基のDNA断片を解読した（Paired-end）。","en":"Genomic DNAs from 30 severe hypertension patients were extracted from peripheral blood cells, and subjected to the enrichment of exon fragments by using SureSelect system (Agilent). We sequenced 100~105 bases from both ends of them with a Illumina HiSeq 2000 system with paired-end mode (fastq format file)."},"dataProviders":[{"name":{"ja":"三木 哲郎","en":"Tetsurou Miki"},"organization":{"name":{"ja":"愛媛大学大学院医学系研究科 老年・神経・総合診療内科学","en":"Department of Geriatric Medicine and Neurology, Ehime University, Graduate School of Medicine"}}}],"researchProjects":[{"name":{"ja":"ミレニアム・ゲノムプロジェクト","en":"Millennium Genome Project"},"url":{"ja":null,"en":null}}],"grants":[{"title":{"ja":"期縦断大規模ゲノム疫学研究による生活習慣病発症の遺伝因子に関するエビデンス構築","en":"Identification of genetic predisposition to non-communicable diseases by a large-scale longitudinal genetic epidemiological study."},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["21390099"]}],"relatedPublications":[],"datasets":["JGAD000016"],"controlledAccessUsers":[]}