{"id":"hum0021","secondaryIds":[],"version":1,"url":"https://humandbs.dbcls.jp/research/hum0021/v1","datePublished":"2015-01-26","versions":[{"version":1,"datePublished":"2015-01-26"},{"version":2,"datePublished":"2021-03-05"},{"version":3,"datePublished":"2021-04-20"}],"title":{"ja":"精神神経疾患の原因解明および診断法・治療法の開発に関する研究","en":"Genetic Analysis in Psychiatric Disorders"},"summary":{"aims":{"ja":"双極性障害関連遺伝子の同定","en":"Identify genes relevant to bipolar disorder"},"methods":{"ja":"Illumina HiSeq 2000を使用したExome解析","en":"Whole exome sequence analysis using Illumina HiSeq 2000"},"targets":{"ja":"健常一卵性双生児3組6例","en":"Three pairs of healthy monozygotic twins"},"url":{"ja":[{"url":"https://www.juntendo-molecular-psychiatry.com/","text":"https://www.juntendo-molecular-psychiatry.com/"}],"en":[{"url":"https://www.juntendo-molecular-psychiatry.com/en/","text":"https://www.juntendo-molecular-psychiatry.com/en/"}]}},"listingSummary":{},"releaseNote":{"ja":"このバージョンでは、健常一卵性双生児3組6例の末梢血から抽出したDNAを用いたExome解析の結果をFastqファイルにて提供する。SureSelect Human All Exon 50 Mb Kit（Agilent社）を用いてExon領域にしぼり、Illumina 社 HiSeq 2000にて平均長100塩基のDNA断片を解読した（Paired-end）。","en":"gDNAs extracted from peripheral blood cells of 3 pairs of healthy monozygotic twins were used for Exome sequencing analysis (fastq format files). Exons were captured using the SureSelect Human All Exon 50 Mb Kit and multiplex sequence was performed with the Illumina HiSeq 2000 sequencer (100 bp, Paired-end)."},"dataProviders":[{"name":{"ja":"加藤 忠史","en":"Tadafumi Kato"},"organization":{"name":{"ja":"理化学研究所 脳科学総合研究センター","en":"RIKEN Brain Science Institute"}}}],"researchProjects":[{"name":{"ja":"精神疾患動態研究チーム","en":"Laboratory of Molecular Dynamics of Mental Disorders"},"url":{"ja":[{"url":"https://www.juntendo-molecular-psychiatry.com/","text":"https://www.juntendo-molecular-psychiatry.com/"}],"en":[{"url":"https://www.juntendo-molecular-psychiatry.com/en/","text":"https://www.juntendo-molecular-psychiatry.com/en/"}]}}],"grants":[{"title":{"ja":"高速シーケンスによる一卵性双生児双極性障害不一致例における遺伝子変異の探索","en":"Search for genetic mutations by next generation sequencing of monozygotic twins discordant for bipolar disorder."},"agency":{"ja":"科学研究費助成事業 挑戦的萌芽研究","en":"KAKENHI Grant-in-Aid for Challenging Exploratory Research"},"grantIds":["21659277"]}],"relatedPublications":[],"datasets":["JGAD000014"],"controlledAccessUsers":[{"principalInvestigator":{"en":"Hailiang Huang"},"affiliation":{"en":"Stanley Center, the Broad Institute"},"country":{"ja":"アメリカ合衆国 (マサチューセッツ州)","en":"Massachusetts, United States"},"researchTitle":{"en":"Asian Bipolar Genetics Network (A-BIG-NET)"},"periodStart":"2021-08-12","periodEnd":"2024-08-29","datasets":["JGAD000014","JGAD000379"]},{"principalInvestigator":{"ja":"中杤 昌弘","en":"Masahiro Nakatochi"},"affiliation":{"ja":"大学院医学系研究科　実社会情報健康医療学, 名古屋大学","en":"Public Health Informatics Unit  Department of Integrated Health Sciences, Nagoya University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"遺伝子解析による脳とこころの病気に対するかかりやすさ（発症脆弱性）や薬の効きめや副作用（治療反応性）等の解明に関する研究","en":"Research on elucidation of susceptibility to brain and mental diseases (vulnerability to disease onset) and efficacy and side effects of drugs (treatment responsiveness) through genetic analysis"},"periodStart":"2023-03-08","periodEnd":"2025-10-27","datasets":["JGAD000379"]}]}