{"id":"hum0006","secondaryIds":[],"version":1,"url":"https://humandbs.dbcls.jp/research/hum0006/v1","datePublished":"2014-01-31","versions":[{"version":1,"datePublished":"2014-01-31"},{"version":2,"datePublished":"2017-06-05"},{"version":3,"datePublished":"2017-09-01"},{"version":4,"datePublished":"2019-02-13"},{"version":5,"datePublished":"2022-08-08"},{"version":6,"datePublished":"2026-06-03"}],"title":{"ja":"脳腫瘍のゲノム・遺伝子解析とその臨床病理学的意義の解明","en":"Genomic and Genetic Analysis of Brain Tumors and Analysis of Their Clinicopathological Significance"},"summary":{"aims":{"ja":"脳腫瘍のゲノム・遺伝子解析とその臨床病理学的意義の解明","en":"The identification of genomic/genetic alterations in brain tumors (gliomas) and analysis of their clinicopathological significance."},"methods":{"ja":"Illumina HiSeq 2000を使用したExome解析","en":"Exome sequence analysis using next generation sequencer (Illumina HiSeq 2000)."},"targets":{"ja":"6症例の初発時の腫瘍部、再発時の腫瘍部、および末梢血の計23検体","en":"Surgical specimen of brain tumors (gliomas) and parid normal peripheral blood cells (Total: 23 samples)."},"url":{"ja":null,"en":null}},"listingSummary":{},"releaseNote":{"ja":"このバージョンでは、アストロサイトーマ6症例の初発時・再発時の腫瘍組織および末梢血（非腫瘍組織）から抽出したDNAを用いたExome解析の結果をbamファイルにて提供する。SureSelect Human All Exon v.4を用いてExon領域にしぼり、Illumina 社 HiSeq 2000にて平均長100塩基を解読した（Paired-end）。","en":"DNAs extracted from brain tumors (6 astrocytomas) and peripheral blood were used for the whole exome sequencing (bam files). Exons were narrowed down by using of SureSelect Human All Exon v.4 and read by Illumina HiSeq 2000 (paired-end: 100 bp)"},"dataProviders":[{"name":{"ja":"斉藤 延人","en":"Nobuhito Saito"},"organization":{"name":{"ja":"東京大学 医学部 脳神経外科","en":"Department of Neurosurgery, The University of Tokyo"}}}],"researchProjects":[{"name":{"ja":"次世代がん研究シーズ戦略的育成プログラム/がん臨床シーズ育成グループ","en":"Project for Development of Innovative Research on Cancer Therapeutics (P-DIRECT)"},"url":{"ja":[{"url":"http://p-direct.mext.go.jp/program/group02/team02.html","text":"http://p-direct.mext.go.jp/program/group02/team02.html"}],"en":[{"url":"http://p-direct.mext.go.jp/english/","text":"http://p-direct.mext.go.jp/english/"}]}}],"grants":[{"title":{"ja":"分子プロファイリングによる新規標的同定を通じた難治がん治療法開発/悪性脳腫瘍克服のための新規治療標的及びバイオマーカーの創出","en":"Development of novel therapeutic strategy and biomarker for the treatment of malignant brain tumors"},"agency":{"ja":"文部科学省 P-DIRECT（次世代がん研究シーズ戦略的育成プログラム）","en":"Ministry of Education, Culture, Sports, Science and Technology Japan (MEXT) P-DIRECT"},"grantIds":null}],"relatedPublications":[{"title":"Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma","doi":"https://doi.org/10.1126/science.1239947","datasets":["JGAD000004"]}],"datasets":["JGAD000004"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000107","JGAD000113","JGAD000216","JGAD000219"]},{"principalInvestigator":{"en":"Frank Attenello"},"affiliation":{"en":"Department of Neurological Surgery, USC Keck School of Medicine"},"country":{"ja":"アメリカ合衆国","en":"United States"},"researchTitle":{"en":"Examining the role of a novel long noncoding RNA, linc02454, in resistance of glioblastoma to temozolomide"},"periodStart":"2023-04-06","periodEnd":"2026-01-31","datasets":["JGAD000215","JGAD000216","JGAD000217","JGAD000218","JGAD000219"]}]}