{"id":"hum0004","version":1,"url":"https://humandbs.dbcls.jp/research/hum0004/v1","datePublished":"2014-07-11","versions":[{"version":1,"datePublished":"2014-07-11"}],"title":{"ja":"上皮成長因子受容体遺伝子異変を有する肺腺癌の体細胞性遺伝子変異プロファイル解明のための分子疫学的研究","en":"Molecular Epidemiological Study of Somatic Mutation Profiles of EGFR Mutation Positive Lung Adenocarcinoma"},"summary":{"aims":{"ja":"アジア人に発症頻度の高いEGFR変異陽性肺腺がんの網羅的遺伝子変異プロファイルを明らかにする","en":"Molecular epidemiological study of somatic mutation profiles of epidermal growth factor receptor: EGFR mutation-positive lung adenocarcinoma"},"methods":{"ja":"全エクソンシークエンシング（Illumina [Genome Analyzer IIx]）","en":"Whole Genome Sequence (Illumina [Genome Analyzer IIx])"},"targets":{"ja":"手術切除された97例の肺腫瘍組織及び非腫瘍組織から抽出したゲノムDNA","en":"97 Japanese lung adenocarcinoma patients as tumor-normal pairs."},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"肺腺癌：97症例\n（日本人）","en":"97 Patients\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome）","en":"NGS (Exome)"}},"releaseNote":{"ja":"このバージョンでは、97症例の腫瘍組織/非腫瘍組織の全エクソン領域（37Mb）のシーケンスデータfastqファイルを提供する。SureSelect Target Enrichment Systemを用いてExon領域にしぼり、Illumina Genome Analyzer IIxにて配列を読んでいる（Paired-end: 2 x 76 bp）。","en":"Whole exome sequencing data in FASTQ format for 97 Japanese lung adenocarcinoma patients (37 MB).Target loci were narrowed down by using of SureSelect Target Enrichment System, and read by Illumina Genome Analyzer IIx (Paired-end: 2 x 76 bp)."},"dataProviders":[{"name":{"ja":"後藤 功一","en":"Koichi Goto"},"organization":{"name":{"ja":"国立がん研究センター東病院 呼吸器内科","en":"Thoracic Oncology Division, the National Cancer Center Hospital East"}}}],"researchProjects":[{"name":{"ja":"国立がん研究センター 先端医療開発センター トランスレーショナルインフォマティクス分野","en":"Division of Translational Informatics, the Exploratory Oncology Research & Clinical Trial Center, the National Cancer Center"},"url":{"ja":[{"url":"https://www.ncc.go.jp/jp/epoc/division/translational_informatics/kashiwa/members/010/index.html","text":"https://www.ncc.go.jp/jp/epoc/division/translational_informatics/kashiwa/members/010/index.html"}],"en":[{"url":"https://www.ncc.go.jp/en/epoc/division/translational_informatics/kashiwa/index.html","text":"https://www.ncc.go.jp/en/epoc/division/translational_informatics/kashiwa/index.html"}]}}],"grants":[{"title":{"ja":"肺腺癌ゲノム解析に基づく治療標的キナーゼの探索","en":"Searching for kinases related to lung cancer based on genomic analysis for lung adenocarcinoma"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["24300345"]}],"relatedPublications":[{"title":"Identification and characterization of cancer mutations in Japanese lung adenocarcinoma without sequencing of normal tissue counterparts.","doi":"https://doi.org/10.1371/journal.pone.0073484","datasets":["JGAD000001"]},{"title":"Clinicopathological characteristics of EGFR mutated adenosquamous carcinoma of the lung.","doi":"https://doi.org/10.1111/pin.12033","datasets":null},{"title":"Immunohistochemical and genetic characteristics of lung cancer mimicking organizing pneumonia.","doi":"https://doi.org/10.1016/j.lungcan.2017.10.001","datasets":null},{"title":"Podoplanin-positive cancer-associated fibroblast recruitment within cancer stroma is associated with a higher number of single nucleotide variants in cancer cells in lung adenocarcinoma.","doi":"https://doi.org/10.1007/s00432-018-2619-3","datasets":null},{"title":"Characterization of the tumor immune-microenvironment of lung adenocarcinoma associated with usual interstitial pneumonia.","doi":"https://doi.org/10.1016/j.lungcan.2018.11.006","datasets":null}],"datasets":["JGAD000001"],"controlledAccessUsers":[{"principalInvestigator":{"en":"Youping Deng"},"affiliation":{"en":"Department of Complementary & Integrative Medicine, University of Hawaii Manoa"},"country":{"ja":"アメリカ合衆国 (ハワイ州)","en":"Hawaii, United States"},"researchTitle":{"ja":"Identification of driver genes and somatic mutations for lung cancer diagnosis and prognosis","en":"Identification of driver genes and somatic mutations for lung cancer diagnosis and prognosis"},"periodStart":"2018-10-04","periodEnd":"2029-07-10","datasets":["JGAD000001"]},{"principalInvestigator":{"ja":"中岡 博史","en":"Hirofumi Nakaoka"},"affiliation":{"ja":"腫瘍ゲノム研究部, 公益財団法人佐々木研究所","en":"Department of Cancer Genome Research, Sasaki Institute"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"肺がん遺伝子解析研究","en":"Genetic analysis of lung cancer"},"periodStart":"2022-08-17","periodEnd":"2026-07-23","datasets":["JGAD000001"]}]}