{"id":"NHA000170","research":"hum0075","url":"https://humandbs.dbcls.jp/dataset/NHA000170","datePublished":"2022-05-27","dateModified":"2022-05-27","values":[{"key":"access-criteria","label":{"ja":"アクセス制限","en":"Access criteria"},"type":"vocabulary","terms":[{"code":"unrestricted-access","label":{"ja":"非制限公開","en":"Unrestricted-access"}}]},{"key":"type-of-data","label":{"ja":"データの種類","en":"Type of data"},"type":"text","text":{"ja":"タイ人B型肝炎 329症例、および、\nタイ人健常対照者 318名のGWAS","en":"GWAS for 329 patients with chronic HBV infection and 318 healthy controls"}}],"experiments":[{"label":"Genotyping by array","values":[{"key":"materials-and-participants","label":{"ja":"材料と対象者","en":"Materials and participants"},"type":"text","text":{"ja":"タイ人B型肝炎（ICD10：B169）：329症例\n（肝がん（ICD10：C220）を併発している患者を含む）\nタイ人健常対照者：318名","en":"329 patients with chronic HBV infection (ICD10: B169)\n[including liver cancer (ICD10: C220) patients]\n318 healthy controls"}},{"key":"disease","label":{"ja":"疾患","en":"Disease"},"type":"disease","diseases":[{"terms":[{"code":"B169","label":{"ja":"急性B型肝炎，デルタ因子及び肝性昏睡を伴わないもの","en":"Acute hepatitis B without delta-agent and without hepatic coma"}}],"name":{"ja":"タイ人B型肝炎","en":"patients with chronic HBV infection"}},{"terms":[{"code":"C220","label":{"ja":"肝細胞癌","en":"Malignant neoplasm: Liver cell carcinoma"}}],"name":{"ja":"肝がん","en":"liver cancer"}}]},{"key":"health-status","label":{"ja":"健康状態","en":"Health status"},"type":"vocabulary","terms":[{"code":"mixed","label":{"ja":"混在","en":"Mixed"}}]},{"key":"subject-count","label":{"ja":"対象者数","en":"Subject count"},"type":"number","numbers":[{"value":647,"unit":null,"high":null}]},{"key":"subject-count-type","label":{"ja":"対象者数の数え方","en":"Counted as"},"type":"vocabulary","terms":[{"code":"individual","label":{"ja":"人数","en":"Individual"}}]},{"key":"population","label":{"ja":"対象集団","en":"Population"},"type":"vocabulary","terms":[{"code":"thai","label":{"ja":"タイ人","en":"Thai"}}]},{"key":"sample-description","label":{"ja":"試料説明","en":"Sample description"},"type":"text","text":{"ja":"末梢血から抽出したgDNA","en":"gDNA extracted from peripheral blood cells"}},{"key":"tissue","label":{"ja":"組織","en":"Tissue"},"type":"vocabulary","terms":[{"code":"peripheral-blood","label":{"ja":"末梢血","en":"Peripheral blood"}}]},{"key":"is-tumor","label":{"ja":"腫瘍 / 非腫瘍","en":"Tumor / normal"},"type":"vocabulary","terms":[{"code":"mixed","label":{"ja":"混在","en":"Mixed"}}]},{"key":"sample-provider","label":{"ja":"試料の入手元","en":"Sample provider"},"type":"text","text":{"ja":null,"en":null}},{"key":"experimental-method","label":{"ja":"実験方法","en":"Experimental method"},"type":"vocabulary","terms":[{"code":"genotyping-by-array","label":{"en":"Genotyping by array"}}]},{"key":"targets","label":{"ja":"測定対象","en":"Target"},"type":"text","text":{"ja":null,"en":null}},{"key":"reagents","label":{"ja":"試薬キット","en":"Reagent kit"},"type":"vocabulary","terms":[{"code":"axiom-2-0-reagent-kit","label":{"en":"Axiom 2.0 Reagent Kit"}}]},{"key":"platform","label":{"ja":"プラットフォーム","en":"Platform"},"type":"vocabulary","terms":[{"code":"affymetrix-axiom-genome-wide-asi-1-array","label":{"en":"Affymetrix Axiom Genome-Wide ASI 1 Array"}}]},{"key":"reference-sequence","label":{"ja":"参照ゲノム","en":"Reference genome"},"type":"vocabulary","terms":[{"code":"grch37","label":{"en":"GRCh37"}}]},{"key":"filtering","label":{"ja":"QC・フィルタリング","en":"QC and filtering"},"type":"text","text":{"ja":"Imputation前の対象SNP除去：SNP call rate < 0.97、MAF < 0.01、HWE P < 1×10^-6\nImputation後の対象SNP除去：info metric < 0.8","en":"pre-imputation QC: SNP call rate < 0.97, MAF P < 0.01, HWE P < 1 x10^-6\nafter imputation QC: SNPs with an info metric < 0.8 were excluded."}},{"key":"imputation","label":{"ja":"インピュテーション","en":"Imputation"},"type":"text","text":{"ja":"IMPUTE2 software (v2.3.2) with 1000 Genomes phase III reference panel","en":"IMPUTE2 v2.3.2 software"}},{"key":"analysis-methods","label":{"ja":"解析方法","en":"Analysis method"},"type":"text","text":{"ja":"Genotyping Console software (v4.2.0.26)","en":"Genotyping Console v4.2.0.26 software"}},{"key":"variant-number","label":{"ja":"バリアント数","en":"Variant count"},"type":"number","numbers":[{"value":6317183,"unit":null,"high":null,"suffix":{"ja":" (常染色体のバリアント)","en":" (autosomal variants)"}}]},{"key":"processed-data-type","label":{"ja":"加工データの種類","en":"Processed data type"},"type":"vocabulary","terms":[{"code":"variant-calls","label":{"ja":"変異コール","en":"Variant calls"}}]},{"key":"policies","label":{"ja":"利用ポリシー","en":"Data use policy"},"type":"vocabulary","terms":[{"code":"nbdc-data-sharing-policy-jgap000001","label":{"ja":"NBDC データ共有ポリシー (JGAP000001)","en":"NBDC data sharing policy (JGAP000001)"}}]}]}],"fileFormats":[{"code":"xlsx","label":{"en":"XLSX"}},{"code":"zip","label":{"en":"ZIP"}}]}