{"id":"JGAD000452","research":"hum0136","url":"https://humandbs.dbcls.jp/dataset/JGAD000452","datePublished":"2021-09-28","dateModified":"2021-09-28","values":[{"key":"access-criteria","label":{"ja":"アクセス制限","en":"Access criteria"},"type":"vocabulary","terms":[{"code":"controlled-access-type-1","label":{"ja":"制限公開（Type I）","en":"Controlled-access (Type I)"}}]},{"key":"type-of-data","label":{"ja":"データの種類","en":"Type of data"},"type":"text","text":{"ja":"日本人B型肝炎ワクチン（ビームゲン）接種者1,193名の個人毎のGenotypingデータ","en":"Genotypes for 1,193 Japanese individuals vaccinated with a HB vaccine (Bimmugen)"}}],"experiments":[{"label":"Genotyping by array","values":[{"key":"materials-and-participants","label":{"ja":"材料と対象者","en":"Materials and participants"},"type":"text","text":{"ja":"日本人B型肝炎ワクチン（ビームゲン）接種者（Total：1,193名）\n・ワクチン低反応群（107名、HBsAb 10mIU/mL以下）\n・ワクチン中反応群（351名、HBsAb 10mIU/mL超、100 mIU/mL以下）\n・ワクチン高反応群（735名、HBsAb 100mIU/mL超）\n日本人B型肝炎ワクチン（ビームゲン）接種者（30歳未満：864名）\n・ワクチン低反応群（56名、HBsAb 10mIU/mL以下）\n・ワクチン中反応群（226名、HBsAb 10mIU/mL超、100 mIU/mL以下）\n・ワクチン高反応群（582名、HBsAb 100mIU/mL超）","en":"1,193 Japanese individuals vaccinated with a HB vaccine (Bimmugen)\n- Low responders (n=107, HBsAb ≤ 10mIU/mL)\n- Intermediate responders (n=351, 10mIU/mL < HBsAb ≤ 100mIU/mL)\n- High responders (n=735, HBsAb >100mIU/mL)\n864 Japanese individuals under the age of 30 years vaccinated with a HB vaccine (Bimmugen)\n- Low responders (n=56, HBsAb ≤ 10mIU/mL)\n- Intermediate responders (n=226, 10mIU/mL < HBsAb ≤ 100mIU/mL)\n- High responders (n=582, HBsAb >100mIU/mL)"}},{"key":"health-status","label":{"ja":"健康状態","en":"Health status"},"type":"vocabulary","terms":[{"code":"healthy","label":{"ja":"健常","en":"Healthy"}}]},{"key":"subject-count","label":{"ja":"対象者数","en":"Subject count"},"type":"number","numbers":[{"value":1193,"unit":null,"high":null}]},{"key":"subject-count-type","label":{"ja":"対象者数の数え方","en":"Counted as"},"type":"vocabulary","terms":[{"code":"individual","label":{"ja":"人数","en":"Individual"}}]},{"key":"population","label":{"ja":"対象集団","en":"Population"},"type":"vocabulary","terms":[{"code":"japanese","label":{"ja":"日本人","en":"Japanese"}}]},{"key":"sample-description","label":{"ja":"試料説明","en":"Sample description"},"type":"text","text":{"ja":"末梢血から抽出したDNA","en":"DNAs extracted from peripheral blood cells"}},{"key":"tissue","label":{"ja":"組織","en":"Tissue"},"type":"vocabulary","terms":[{"code":"peripheral-blood","label":{"ja":"末梢血","en":"Peripheral blood"}}]},{"key":"is-tumor","label":{"ja":"腫瘍 / 非腫瘍","en":"Tumor / normal"},"type":"vocabulary","terms":[{"code":"normal","label":{"ja":"非腫瘍","en":"Normal"}}]},{"key":"sample-provider","label":{"ja":"試料の入手元","en":"Sample provider"},"type":"text","text":{"ja":null,"en":null}},{"key":"experimental-method","label":{"ja":"実験方法","en":"Experimental method"},"type":"vocabulary","terms":[{"code":"genotyping-by-array","label":{"en":"Genotyping by array"}}]},{"key":"targets","label":{"ja":"測定対象","en":"Target"},"type":"text","text":{"ja":null,"en":null}},{"key":"platform","label":{"ja":"プラットフォーム","en":"Platform"},"type":"vocabulary","terms":[{"code":"affymetrix-axiom-genome-wide-asi-1-array","label":{"en":"Affymetrix Axiom Genome-Wide ASI 1 Array"}}]},{"key":"reference-sequence","label":{"ja":"参照ゲノム","en":"Reference genome"},"type":"vocabulary","terms":[{"code":"grch37","label":{"en":"GRCh37"}}]},{"key":"filtering","label":{"ja":"QC・フィルタリング","en":"QC and filtering"},"type":"text","text":{"ja":"overall call rate < 0.95、SNP call rate < 0.95、\nHWE P < 0.001、MAF < 0.05、Regression P < 0.05","en":"overall call rate < 0.95, SNP call rate < 0.95,\nHWE P < 0.001, MAF < 0.05, Regression P < 0.05"}},{"key":"analysis-methods","label":{"ja":"解析方法","en":"Analysis method"},"type":"text","text":{"ja":"GenCall software（Genotyping Console ver. 4.2.0.26）","en":"GenCall software (Genotyping Console ver. 4.2.0.26)"}},{"key":"variant-number","label":{"ja":"バリアント数","en":"Variant count"},"type":"number","numbers":[{"value":22044,"unit":null,"high":null,"prefix":{"ja":"① 低反応群: 0、中反応群: 1、高反応群: 2、とした回帰分析(年齢・性別で補正): ","en":"I. Regression analysis for low (0), intermediate (1), and high (2) responders (covariates: age and gender): "},"suffix":{"ja":" SNPs (Figure 2)","en":" SNPs (Figure 2)"}},{"value":21580,"unit":null,"high":null,"prefix":{"ja":"② 30歳未満のみを対象とした、低反応群: 0、中反応群: 1、高反応群: 2、とした回帰分析(年齢・性別で補正): ","en":"II. Regression analysis for low (0), intermediate (1), and high (2) responders under the age of 30 years (covariates: age and gender): "},"suffix":{"ja":" SNPs (Supplementary Figure 4)","en":" SNPs (Supplementary Figure 4)"}},{"value":23765,"unit":null,"high":null,"prefix":{"ja":"③ 低反応群: 0、高反応群: 1、とした回帰分析(年齢・性別で補正): ","en":"III. Regression analysis for low (0) and high (1) responders (covariates: age and gender): "},"suffix":{"ja":" SNPs (Supplementary Figure 5)","en":" SNPs (Supplementary Figure 5)"}}]},{"key":"has-phenotype-data","label":{"ja":"表現型データの有無","en":"Phenotype data"},"type":"vocabulary","terms":[{"code":"included","label":{"ja":"あり","en":"Included"}}]},{"key":"policies","label":{"ja":"利用ポリシー","en":"Data use policy"},"type":"vocabulary","terms":[{"code":"nbdc-data-sharing-policy-jgap000001","label":{"ja":"NBDC データ共有ポリシー (JGAP000001)","en":"NBDC data sharing policy (JGAP000001)"}}]}]}],"dataVolume":34403456026,"fileFormats":[{"code":"cel","label":{"en":"CEL"}},{"code":"csv","label":{"en":"CSV"}}]}