{"id":"JGAD000120","research":"hum0108","url":"https://humandbs.dbcls.jp/dataset/JGAD000120","datePublished":"2020-09-28","dateModified":"2020-11-18","values":[{"key":"access-criteria","label":{"ja":"アクセス制限","en":"Access criteria"},"type":"vocabulary","terms":[{"code":"controlled-access-type-1","label":{"ja":"制限公開（Type I）","en":"Controlled-access (Type I)"}}]},{"key":"type-of-data","label":{"ja":"データの種類","en":"Type of data"},"type":"text","text":{"ja":"メチル化アレイ","en":"Methylation array"}}],"experiments":[{"label":"メチル化アレイ","values":[{"key":"materials-and-participants","label":{"ja":"材料と対象者","en":"Materials and participants"},"type":"text","text":{"ja":"パニック症患者（ICD10：F410）：48症例\n対照健常者：48名\n（一卵性双生児不一致例1組を含む）","en":"Panic disorder (ICD10: F410) : 48 cases\nHealthy controls: 48 samples\n(including a pair of discordant monozygotic twins)"}},{"key":"disease","label":{"ja":"疾患","en":"Disease"},"type":"disease","diseases":[{"terms":[{"code":"F410","label":{"ja":"恐慌性＜パニック＞障害［挿間性発作性不安］","en":"Panic disorder [episodic paroxysmal anxiety]"}}],"name":{"ja":"パニック症患者","en":"Panic disorder"}}]},{"key":"health-status","label":{"ja":"健康状態","en":"Health status"},"type":"vocabulary","terms":[{"code":"mixed","label":{"ja":"混在","en":"Mixed"}}]},{"key":"subject-count","label":{"ja":"対象者数","en":"Subject count"},"type":"number","numbers":[{"value":96,"unit":null,"high":null}]},{"key":"subject-count-type","label":{"ja":"対象者数の数え方","en":"Counted as"},"type":"vocabulary","terms":[{"code":"individual","label":{"ja":"人数","en":"Individual"}}]},{"key":"sample-description","label":{"ja":"試料説明","en":"Sample description"},"type":"text","text":{"ja":"末梢血から抽出したDNA","en":"DNAs extracted from peripheral blood cells"}},{"key":"tissue","label":{"ja":"組織","en":"Tissue"},"type":"vocabulary","terms":[{"code":"peripheral-blood","label":{"ja":"末梢血","en":"Peripheral blood"}}]},{"key":"is-tumor","label":{"ja":"腫瘍 / 非腫瘍","en":"Tumor / normal"},"type":"vocabulary","terms":[{"code":"normal","label":{"ja":"非腫瘍","en":"Normal"}}]},{"key":"sample-provider","label":{"ja":"試料の入手元","en":"Sample provider"},"type":"text","text":{"ja":null,"en":null}},{"key":"experimental-method","label":{"ja":"実験方法","en":"Experimental method"},"type":"vocabulary","terms":[{"code":"methylation-array","label":{"en":"Methylation array"}}]},{"key":"targets","label":{"ja":"測定対象","en":"Target"},"type":"text","text":{"ja":null,"en":null}},{"key":"reagents","label":{"ja":"試薬キット","en":"Reagent kit"},"type":"vocabulary","terms":[{"code":"ez-dna-methylation-kit","label":{"en":"EZ DNA Methylation Kit"}},{"code":"infinium-humanmethylation450-beadchip-kit","label":{"en":"Infinium HumanMethylation450 BeadChip Kit"}}]},{"key":"platform","label":{"ja":"プラットフォーム","en":"Platform"},"type":"vocabulary","terms":[{"code":"illumina-infinium-humanmethylation450","label":{"en":"Illumina Infinium HumanMethylation450"}}]},{"key":"reference-sequence","label":{"ja":"参照ゲノム","en":"Reference genome"},"type":"vocabulary","terms":[{"code":"grch37","label":{"en":"GRCh37"}}]},{"key":"filtering","label":{"ja":"QC・フィルタリング","en":"QC and filtering"},"type":"text","text":{"ja":"detection P value < 0.01のβ値は欠測値とした上で以下の条件を満たすprobeについて解析対象とした\n(1) probe call rate >95%\n(2) 性染色体上にない\n(3) probeがその配列にマイナーアリル頻度が5%以上のSNPを含まない\n(4) probeがゲノム上のターゲット領域以外にハイブリダイズする可能性があると報告されていない*1","en":"(1) detection p value of each probe ≥ 0.01\n(2) probe call rate >95%\n(3) on autosomal chromosomes\n(4) does not include SNP which minor allele frequency is greater than or equal to 5%\n(5) hybridizes to a specific sequence*1"}},{"key":"normalization","label":{"ja":"正規化","en":"Normalization"},"type":"text","text":{"ja":"(1) Lumi: quantile normalizationbeta mixture quantile*2\n(2) BMIQ normalization*3\n(3) ComBat*4","en":"(1) Lumi: quantile normalizationbeta mixture quantile*2\n(2) BMIQ normalization*3\n(3) ComBat*4"}},{"key":"analysis-methods","label":{"ja":"解析方法","en":"Analysis method"},"type":"text","text":{"ja":"iScan system and GenomeStudio Software","en":"iScan system and GenomeStudio Software"}},{"key":"probe-number","label":{"ja":"プローブ数","en":"Probe count"},"type":"number","numbers":[{"value":376602,"unit":null,"high":null,"suffix":{"ja":" (メチル化サイト)","en":" (methylation sites)"}}]},{"key":"policies","label":{"ja":"利用ポリシー","en":"Data use policy"},"type":"vocabulary","terms":[{"code":"nbdc-data-sharing-policy-jgap000001","label":{"ja":"NBDC データ共有ポリシー (JGAP000001)","en":"NBDC data sharing policy (JGAP000001)"}}]}]}],"dataVolume":438575472,"fileFormats":[{"code":"txt","label":{"en":"TXT"}}]}